甲状腺功能亢进症孕母对新生儿胎龄、出生体质量及甲状腺功能的影响  

Influence of Maternal Hyperthyroidism on Neonatal Gestational Age,Birth Weight and Thyroid Function

作　　者：岳波[1] Yue bo(The Second Affiliated Hospital of Qiqihar Medical School, Heilongjiang Qiqihar 161006, China)

机构地区：[1]黑龙江齐齐哈尔医学院附属第二医院,黑龙江齐齐哈尔161006

出　　处：《儿科药学杂志》2017年第11期5-8,共4页Journal of Pediatric Pharmacy

摘　　要：目的:探讨母亲甲状腺功能亢进症(甲亢)对新生儿胎龄、体质量及甲状腺功能的影响。方法:选择我院收治的90例妊娠期甲亢患者,根据其治疗方式分为试验组1和试验组2,每组45例,其中试验组1采用非抗甲状腺药物治疗,试验组2采用抗甲状腺药物治疗,比较两组患者的治疗效果。同时选取45例健康产妇,设为对照组,比较三组产妇的新生儿体质量、胎龄和性别。结果:三组新生儿体质量两两比较差异均有统计学意义(P<0.05),试验组1<试验组2<对照组,性别及胎龄比较差异无统计学意义(P>0.05)。不良妊娠结局的发生率试验组1为42.22%(19/45),试验组2为8.89%(4/45),对照组为2.22%(1/45),试验组1的不良妊娠结局发生率均明显高于试验组2及正常对照组(P<0.05)。三组TSH、FT3、FT4水平两两比较差异均有统计学意义(P<0.05),试验组1>试验组2>对照组。结论:妊娠期甲亢应用抗甲状腺药物治疗后能够改善新生儿的甲状腺功能,减少妊娠不良结局。Objective： To study the effect of maternal hyperthyroidism on neonatal gestational age,birth weight and thyroid function.Methods： Ninety cases with maternal hyperthyroidism of our hospital were selected,all cases were divided into the experimental group 1 and experimental group 2,45 cases in each group. The experimental group 1 was given non-anti-thyroid medication,the experimental group 2 was given anti-thyroid medication,the effect of two groups was compared. Forty-five cases of healthy puerperae were select at the same time,as the control group,neonatal gestational age,birth weight,gender,and thyroid function of three groups were compared.Results： There were significant differences in neonatal birth weight between the three groups（ P〈0. 05）,of which the experimental group1〈experimental group 2〈control group,and there were no significant differences in the gender and gestational age between the three groups（ P〉0. 05）. The incidence of adverse pregnancy outcomes of experimental group 1,experimental group 2 and control group were 42. 22%（ 19/45）,8. 89%（ 4/45） and 2. 22%（ 1/45） respectively,which in experimental group 1 was significantly higher than that in the experimental group 2 and control group（ P〈0. 05）. The differences of TSH,FT3 and FT4 levels between the three groups were statistically significant（ P〈0. 05）,among which the experimental group 1〉experimental group 2〉control group. Conclusion： The application of antithyroid drugs can improve the thyroid function and reduce the adverse pregnancy outcomes in pregnant women with hyperthyroidism.

关 键 词：甲状腺功能亢进症 新生儿 体质量 甲状腺功能 

分 类 号：R722.1[医药卫生—儿科]