甘枣宁颗粒治疗非酒精性脂肪肝临床疗效及安全性分析  

Clinical efficacy and safety of ganzaoning granule in the treatment of patients with nonalcoholic fatty liver

作　　者：陆检英 郑国银[2] 彭浩[2] 李欢 周海燕 张高彬 Lu Jianying Zheng Guoyin Peng Hao et al(Department of Traditional Chinese Medicine, Jing＇ an Hospital ofIntegrated Traditional Chinese and Western Medicin Hefei 230000, Anhui Province, China)

机构地区：[1]安徽静安中西医结合医院中医科,合肥市230000 [2]第二军医大学附属长海医院中医科

出　　处：《实用肝脏病杂志》2017年第6期709-712,共4页Journal of Practical Hepatology

基　　金：国家科技支撑计划973项目(编号:2012BA141B05);国家自然科学基金资助项目(编号:81102774/81573653)

摘　　要：目的探讨甘枣宁颗粒治疗非酒精性脂肪肝患者的临床疗效及安全性。方法 2015年10月~2016年10月收治的300例非酒精性脂肪肝患者,采取随机数字表法将其分成两组,每组150例。两组患者均接受脂肪肝中医预防保健服务包指导干预,给药组在此基础上给予甘枣宁颗粒治疗,比较两组治疗前后中医证候积分、生化指标、临床疗效及不良反应发生情况。结果在3个月治疗末,给药组总有效率为93.3%,显著高于对照组为61.3%(P<0.01);给药组中医证候积分(9.3±2.1)显著低于对照组【(12.8±3.6),P<0.01】;给药组血清ALT、AST、TC、TG水平分别为(38.1±12.4)U/L、(36.4±9.6)U/L、(2.1±0.4)mmol/L、(5.2±1.4)mmol/L,均显著低于对照组[分别为(54.2±9.3)U/L、(50.±11.2)U/L、(2.7±0.4)mmol/L、(6.5±1.2)mmol/L,P<0.01]。结论甘枣宁颗粒联合脂肪肝中医预防保健服务包治疗非酒精性脂肪肝患者有较好的临床疗效。Objective To investigate the efficacy and safety of Ganzaoning granules in the treatment ofpatients with nonalcoholic fatty liver. Methods 300 patients with nonalcoholic fatty liver were recruited in ourhospital between October 2015 and October 2016, and they were randomly divided into two groups, with 150 casein each group. All patients were given a regular diet and exercise therapy, and 150 patients were treated withGanzaoning granules at the base of diet and exercise therapy. TCM syndrome scores, blood biochemical parameter,clinical efficacy and adverse reactions were observed. Results At the end of 3 month treatment, the total effectiverate in the Ganzaoning granule-treated group was 93.3%, significantly higher than 61.3% in the control group（P〈0.01）; TCM syndrome score was （9.3±2.1）, significantly lower than [ （12.8±3.6）, P〈0.01] in the control group;serum ALT, AST, TC and TG levels were（38.1±12.4）U/L,（36.4±9.6）U/L,（2.1±0.4）mmol/L and（5.2±1.4）mmol/L, significantly lower than [ （54.2±9.3）U/L,（50±11.2）U/L,（2.7±0.4）mmol/L and （6.5±1.2）mmol/L in thecontrol, respectively, P〈0.01]. Conclusion Ganzaoning granule treatment at the base of diet and exercise therapy inpatients with nonalcoholic fatty liver hasa good clinical efficacy and safety.

关 键 词：非酒精性脂肪肝 甘枣宁颗粒 临床疗效 

分 类 号：R259[医药卫生—中西医结合]