慢性阻塞性肺疾病血清激活素A表达的临床意义  

Measurement and clinical application of activin A in chronic obstructive pulmonary disease

作　　者：张俊[1] 冯艳[1] 陈如华[1] 丁辉[1] 

机构地区：[1]宜兴市人民医院呼吸内科,江苏宜兴214200

出　　处：《临床肺科杂志》2017年第12期2135-2137,共3页Journal of Clinical Pulmonary Medicine

基　　金：江苏省卫计委科教强卫项目(QNRC2016210);江苏省卫生厅医改科研课题基金(YG201408);国家自然科学基金(No 81500049)资助

摘　　要：目的探讨慢性阻塞性肺疾病(慢阻肺)患者血清激活素A(Activin A)表达变化对判断病情严重程度的临床意义。方法选择90例慢阻肺急性加重期(AECOPD)患者作为实验组,根据肺功能分轻-中度组50例,重-极重度组40例,并根据治疗分为慢阻肺缓解组和非缓解组,以健康体检者60例作为对照组;采用酶联免疫吸附双抗体夹心法测定各组血清Activin A水平。结果与健康对照组相比,慢阻肺患者血清Activin A明显增高(P<0.05);肺功能重-极重度AECOPD患者血清Activin A水平高于轻-中度组(P<0.05),经治疗慢阻肺缓解组Activin A水平低于非缓解组(P<0.05)。进一步研究发现:AECOPD患者血清Activin A含量随FEV_1%降低而增高,呈负相关(r=-0.84,P<0.05),与FEV_1/FVC呈显著负相关(r=-0.62,P<0.05)。结论 Activin A调控慢阻肺气道炎症,对反映AECOPD病情严重程度具有重要临床意义。bjective To investigate the clinical significance of activin A in COPD patients. Metliods 90COPD patients were divided into two subgroups： 50 cases in the mild moderate group and 40 cases based on disease severity, or the remission group and the non-remission group based on 60 healthy people were taken as the control group. All cases were followed with pulmonary function test with FEVi 8and FEVi/FVC as indexes, and the level of activin Awas detected by enzyme linked immunosorbent assay. Results The level of serumactivin A in COPD was significantly higher than in healthy people （ P 〈 um activin A in the severe group and the non-remission group was higher than in the mild group and the remission group （ P 〈 0. 05 ） . The serum concentration of activin A was negatively correlated with FEVi （ r = -0.84 ,P 〈 0. 05 ） and FEVi /FVC （ r = - 0. 6 2, P 〈 0. 05 ） . Conclusion Activin Ah as important clinical application with par-ticipating airway inflammation and judging severity of COPD.

关 键 词：慢性阻塞性肺疾病 激活素A 

分 类 号：R563.9[医药卫生—呼吸系统]