峨眉唐松草碱对离体大鼠心肌缺血再灌注损伤的保护作用  

THE PROTECTIVE EFFECTS OF METHOXYADIANTIFOLINE ON THE ISCHEMIA-REPERFUSION INDUCED INJURY IN ISOLATED RAT MYOCARDIUM

作　　者：刘红[1] 贾菊芳[2] 胡本容[2] 钱家庆[2] 

机构地区：[1]湖北恩施医专药理教研室,445000 [2]同济医科大学药理教研室,汉口430030

出　　处：《中国药理学通报》1991年第5期337-341,共5页Chinese Pharmacological Bulletin

摘　　要：峨眉唐松草碱(methoxyadiantifoline 5μmol/L)显著降低大白鼠离体灌流心脏缺血再灌注损伤所致心室纤颤的发生率、延长窦性心律时间、减少心肌细胞中乳酸脱氢酶的释放及丙二醛的生成,显示其具有保护心肌及抑制脂质过氧化作用,效果与维拉帕米近似。Methoxyadiantifoline ( MAF) is a new alkloid isolated from Thalictrum Omeience W.T.Wang.During 3 min reperfusion after 10 min of coronary ligation, MAF 5 μmol/L significantly decreased the incidence of isolated rat hearts with ventricular arrhythmias ( VF and VT ) . It delayed the onset of ventricular fibrillation and shortened its duration and markedly prolonged the time of normal sinus rhythm. It also significantly decreased the release of LDH from the myocardium in isolated rat hearts. In addition , MAF 5 μmol/L could decrease the heart rate and coronary resistance. The results suggest that MAF possessed protective effects on the reperfusion injury in isolated rat hearts.

关 键 词：峨眉唐松草碱 心肌缺血 再灌注损伤 

分 类 号：R972[医药卫生—药品]