叶酸补充与先天性心脏病发病关系的人群研究  

Population-based study on the relationship between folic acid supplementation and the occurrence risk of congenital heart defects

作　　者：王定美[1] 黄国英[1,2] 

机构地区：[1]复旦大学附属儿科医院,上海201102 [2]上海市出生缺陷防治重点实验室,上海201102

出　　处：《复旦学报（医学版）》2017年第6期806-810,共5页Fudan University Journal of Medical Sciences

基　　金：国家重点研发计划项目(2016YFC1000506);国家自然科学基金(81370198;81570283);上海市公共卫生三年行动计划重点项目(2015-82)~~

摘　　要：先心病是最常见的先天性畸形,其发生受遗传因素和环境因素的共同影响。近年来,关键营养因素作为围孕期重要的可调节的环境因素与先心病的关系引起越来越多的关注,其中最具有代表性的是围孕期母体叶酸补充,许多研究资料显示,围孕期叶酸补充有助于降低先心病的发生风险;但阐明叶酸与先心病发病之间的关系仍然面临许多挑战,值得深入研究。Congenital heart disease(CHD)is the most common congenital malformations.It occurs under the combined effect of genetic and environmental factors.In recent years,the correlation of key nutritional factors,the modifiable environmental factors,with the occurrence risk of CHD has attracted increasing attention.One of the most representative key nutritional factors is folic acid,and many studies suggest that maternal folic acid supplementation during periconceptional period could reduce the risk of CHD occurrence.However,many challenges remain in order to clarify the relationship between folic acid and CHD,which is worthy of further study.

关 键 词：叶酸 先天性心脏病 围孕期 

分 类 号：R715.3[医药卫生—妇产科学]