滨州地区青年人胃癌临床病理特征分析  

Clinicalpathologic Characteristics of Young Gastric Carcinoma in Binzhou Area

作　　者：孔彩霞 牟清海[1] 秦密密 曹璋[1] 

机构地区：[1]滨州医学院病理学教研室,山东滨州256600

出　　处：《科技视界》2017年第21期71-72,共2页Science & Technology Vision

基　　金：山东省高等学校科技计划项目(J16LK54);山东省自然科学基金(No.ZR2016HL29)

摘　　要：目的:探讨滨州地区青年人胃癌的临床病理特点,提高青年人胃癌诊疗水平,以达到早发现、早诊断及有效治疗的目的。方法:收集滨州医学院附属医院2010年11月-2016年12月滨州医学院附属医院收治的60例青年人胃癌患者及221例中老年人胃癌,对两组人群胃癌临床病理特点、耐药相关蛋白、P53免疫表型进行分析比较。结果:青年组与老年组胃癌比较,弥漫型更多见,肿瘤大小较老年组小,耐药相关蛋白MDR-1在青年组与中老年组均有表达,青年组中阳性表达更高,差异有统计学意义(P<0.05)。结论:滨州地区青年组胃癌分化更低,恶性程度高,耐药性相关蛋白呈高表达状态,后续治疗耐药发生率更高,对青年人胃癌应更加重视,早期诊断、及时治疗是关键。Objective To provide data for the further study of gastric cancer in young people in the diagnosis and evaluation of prognosis of young patients with gastric cancer. Methods The clinical cases of 281 gastric cancer patients treated at the Binzhou Medical University Hospital of from November ？ 1 st 2010 to December 31 st 2016 were collected retrospectively. Results Gastric cancer pathology type of diffuse was the most common in young, tumor size is smaller than that in elderly. The positive expression rate of MDR-1 in young gastric cancer tissues was significantly higher than that in the elderly gastric cancer tissues（ P〈 0. 05）. Conclusions Gastric cancer in young patients have unique clinicopathological features, high expression of MDR-1. It still needs large sample prospective studies to identify differences of clinical pathological characteristics and prognosis between young and elderly patients with gastric cancer.

关 键 词：胃癌 青年人 病理特征 

分 类 号：S851.347[农业科学—预防兽医学]