唑来膦酸联合骨水泥技术治疗老年骨质疏松性骨折的临床研究  

Clinical Research on Zoledronic Acid Combined with Bone Cement Technology in Treating Senile Osteoporosis Fracture

作　　者：路绪超[1] 许杰[1] 尚志恒[1] 孟双全[1] 

机构地区：[1]开封市第二人民医院,河南开封475000

出　　处：《中国初级卫生保健》2017年第11期64-65,共2页Chinese Primary Health Care

摘　　要：目的分析老年骨质疏松性骨折采用骨水泥技术联合唑来膦酸治疗的效果。方法选取我院收治的骨质疏松性骨折老年患者68例,随机分成治疗组(34例)、对照组(34例)。对照组单纯行经皮骨水泥注入术,治疗组采用经皮骨水泥注入术+唑来膦酸治疗,比较两组的疼痛评分、骨密度和骨代谢指标。结果治疗组治疗后的疼痛评分低于对照组,骨密度高于常规组,脂代谢指标(t P1NP、OCN和βCTX)改善效果优于对照组,两组数据比较有统计学意义(P<0.05)。结论老年骨质疏松性骨折患者经皮骨水泥注入术后给予唑来膦酸注射液治疗,能减轻术后疼痛,改善骨代谢,提高骨密度,值得临床上推广。OBJECTIVE To analyze the curative effects of zoledronic acid combined with bone cement technology in treating senile os-teopotosis fracture.METHODS 68 cases of patients with senile osteopotosis fracture admitted and treated in target hospital were ran-domly divided into treatment group and contrast group with each group 34 cases.Patients in the contrast group were given merely per-cutaneous bone cement injection,while patients in the treatment group were given percutaneous bone cement injection combined withzoledronic acid treatment.It compared the pain scores,BMD and bone metabolism index.RESULTS After treatment,the pain scoresin the treatment group were lower than the contrast group.The BMD in the treatment group was higher than the contrast group.Thebone metabolism index(t P1 NP,OCN and βCTX) improvement effects in the treatment group were superior to the contrast group.Thecomparison between both groups showed statistical significance(P<0.05).CONCLUSION Zoledronic acid combined with percutane-ous bone cement injection in treating senile osteopotosis fracture patients could effective relieve the patients' post-operative pains,im-prove the bone metabolism and increase the BMD.Thus,it deserved to be widely promoted in the clinical field.

关 键 词：骨质疏松性骨折 骨水泥 唑来膦酸 骨代谢 

分 类 号：R683[医药卫生—骨科学]