低剂量罗红霉素和联合脾胺肽对支气管扩张患者外周血INF-γ、IL-4及CD4^+、CD8^+细胞影响及其临床疗效评价  

Study on the effect of low dose roxithromycin and spleen aminopeptidase on INF-γ,IL-4,CD4^+,CD8^+ in peripheral blood of patients with bronchiectasis and evaluation on its clinical effect

作　　者：王永仓[1] 孟婷[1] 孙莹[1] 王冬舫 孙砚诚 

机构地区：[1]保定市第二中心医院呼吸内科,河北保定072750

出　　处：《中国卫生检验杂志》2017年第20期2944-2946,2949,共4页Chinese Journal of Health Laboratory Technology

基　　金：保定市科技支撑计划(16ZF090)

摘　　要：目的探讨低剂量罗红霉素和脾氨肽联合治疗支气管扩张症稳定期的临床效果。方法选取2013年3月-2016年1月于本院诊治的支气管扩张症稳定期患者90例进行研究,随机原则分为研究组(45例)和对照组(45例),对照组给予祛痰平喘等常规治疗,治疗组在常规治疗基础上加用罗红霉素及脾氨肽口服冻干粉,连续应用6个月。比较2组患者外周血INF-γ和IL-4的水平及CD4^+及CD8^+细胞改变情况、呼吸困难评分、生活质量评分、病情急性发作次数、咳痰量、胸部CT影像学评分情况。结果治疗后,研究组患者INF-γ/IL-4及CD4^+/CD8^+较对照组好转;胸部CT总评分、扩张支气管的厚度评分、病变肺叶面积评分、病变组织占肺叶面积评分均较治疗前、对照组明显下降;2组患者治疗后的呼吸困难评分、生活质量评分、病情急性发作次数、咳痰量均较治疗前降低,差异均有统计学意义(P<0.05)。结论对临床中支气管扩张症稳定期患者实施低剂量罗红霉素和脾氨肽联合治疗,效果显著,值得推广。Objective To evaluate the clinical effect of low dose roxithromycin and spleen aminopeptidase in the treatment of bronchiectasis in stable period. Methods 90 cases of bronchiectasis in stable period in our hospital from March 2013 to January 2016 were chosen and randomly divided into the study group（ 45 cases） and the control group（ 45 cases）. The control group was treated with conventional therapy,while the study group was treated by roxithromycin and spleen aminopeptidase for six month. INF-γ,IL-4,CD4-＋,CD8-＋in peripheral blood,affection of dyspnea score,quality of life score and the severity of acute attack times,amount of sputum,chest CT images learning score were compared between the two groups. Results After treatment,INF-γ/IL-4 and CD4-＋/CD8-＋of the study group were higher than the control group; the total score of chest CT images,bronchiectasis thickness score,lesion lobe score,lesion accounted for in the area of the lobe score in the study group decreased significant compared with that in the control group before the treatment; after treatment,the dyspnea score,life quality score and the severity of acute attack times,amount of sputum in two groups were significantly lower than that before treatment,with the differences statistically significant（ P〈0. 05）. Conclusion Low dose roxithromycin combined with spleen aminopeptidase is effective in treating the patients with bronchial dilatation in stable stage,which is worthy of promotion.

关 键 词：罗红霉素 低剂量 脾胺肽 支气管扩张症稳定期 免疫状况 疗效 

分 类 号：R562.22[医药卫生—呼吸系统]