DNA甲基化与哺乳动物生殖  

DNA Methylation In Mammalian Reproduction

作　　者：田鎏 张昌军 刁红录 

机构地区：[1]湖北医药学院附属人民医院生殖医学中心,十堰442000 [2]湖北医药学院生物医学工程学院,十堰442000 [3]胚胎干细胞湖北省重点实验室,十堰442000

出　　处：《中国细胞生物学学报》2017年第10期1374-1378,共5页Chinese Journal of Cell Biology

基　　金：湖北省自然科学基金(批准号:2015CFB543);湖北医药学院创新团队(批准号:2014CXX03;FDFR201604);湖北医药学院重点学科建设项目资助的课题~~

摘　　要：DNA甲基化是表观遗传水平基因表达调控的重要方式之一,对哺乳动物的生长发育具有重要作用。原始生殖细胞的甲基化水平、胚胎发育过程中甲基化的重排以及胎盘发育过程中异常甲基化都与生殖过程密切相关。男性不育、女性自然流产及辅助生殖技术(assisted reproductive technology,ART)的应用也与DNA甲基化有关,通过引起DNA甲基化变化从而影响表观遗传调控的变化。该文对DNA甲基化与哺乳动物生殖作一综述,并阐述DNA甲基化与男性不育、自然流产及ART过程的关系。DNA methylation is one of the major modifications in epigenetic level, and plays an important role in mammalian growth and development. The DNA methylation level of primordial germ cells and methylation rearrangement during embryonic development, and placentation of abnormal methylation is closely related to the reproductive process. Otherwise, DNA methylation also related to male infertility, spontaneous abortion and ART application, which affects the epigenetic process. In this paper, DNA methylation in mammalian reproductive was reviewed and expounded with the relationship between male infertility, spontaneous abortion and the ART process and DNA methylation relationship.

关 键 词：DNA甲基化 表观遗传 哺乳动物 生殖 

分 类 号：Q953[生物学—动物学]