Asymmetric Synthesis and Antitumor Activity of Spiro- Oxadiazole Derivatives from 1,4：3,6-Dianhydro-D-fructose  

作　　者：Wenke Xu Yongxun Ge Yu Hou Yingju Liu Yingchun Hua Weiwei Han Zhiyan Qin Fengwu Liu 

机构地区：[1]School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China [2]Collaborative Innovation Center of Henan New Drug Research and Safety Evaluation, Zhengzhou, Henan 450001, China [3]Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan 450007, China [4]Oepartment of Medicine, Kaifeng University, Kaifeng, Henan 475000, China

出　　处：《Chinese Journal of Chemistry》2017年第9期1437-1444,共8页中国化学（英文版）

基　　金：We gratefully acknowledge financial support from the National Natural Science Foundation of China （No. 21372207）.

摘　　要：A series of spiro-oxadiazoles were synthesized from 1,4：3,6-dianhydro-D-fructose and hydrazides via a stereoselective two-step reaction sequence. The structures of newly synthesized compounds were established by spectral analysis. The absolute configuration of compound 2a was further confirmed by single crystal X-ray analysis. All the synthesized compounds were screened for their in vitro antitumor activity, showing that these compounds have poor inhibitory activities against A549, MGC-803 tumor cells.A series of spiro-oxadiazoles were synthesized from 1,4：3,6-dianhydro-D-fructose and hydrazides via a stereoselective two-step reaction sequence. The structures of newly synthesized compounds were established by spectral analysis. The absolute configuration of compound 2a was further confirmed by single crystal X-ray analysis. All the synthesized compounds were screened for their in vitro antitumor activity, showing that these compounds have poor inhibitory activities against A549, MGC-803 tumor cells.

关 键 词：1 4：3 6-dianhydro-D-froctose spiro-oxadiazole single crystal X-ray analysis antitumor activity 

分 类 号：O626[理学—有机化学] O621.34[理学—化学]