三叉颈核复合体的解剖学研究进展  

Research progress on the anatomy of trigeminocervical complex

作　　者：张立勇[1] 陈恒林[1] 崔永华[1] 夏咏本[1] 韩清[1] 

机构地区：[1]南通大学附属建湖医院神经外科头痛组,江苏省建湖县224700

出　　处：《中华解剖与临床杂志》2017年第5期429-432,共4页Chinese Journal of Anatomy and Clinics

摘　　要：目的 以解剖视角系统总结头部痛觉二级神经元研究进展,寻求神经外科介入头痛治疗的切入点.方法 以数十个与＂头部痛觉二级神经元＂相关联的关键词,无时间范围限制,多批次检索了PubMed、Web of Science、OVID系列医学数据库,特别是深圳市迈特思创科技有限公司外文医学信息资源检索平台（FMRS）及其原文传递系统,历经多次检索—阅读—再检索—再阅读过程,筛选出历年以不同名称表述的头部痛觉二级神经元相关研究,总结其解剖学、生理学、病理学、胚胎学以及临床研究成果,分析三叉颈核复合体（TCC）在生理、病理状态下发挥作用的规律.结果 TCC是各类头痛共同的二级神经元,其会聚传入、会聚活化、会聚敏化在头痛的发生、发展,特别是慢性化过程中发挥重要作用.结论 TCC可作为现阶段头痛对症治疗的靶点之一,其会聚神经作为手术入路具有较大的探索空间.Objective To explore the main point of interventional therapy for the treatment of cephalalgia by summarizing the research progress of the head nociceptive second-order neurons mainly via neuroanatomy. Methods The literatures were retrieved in batch amounts in PubMed database, Web of Science, OVID medicine series, especially foreign medical information resources retrieval platform （FMRS） and text messaging system of Shenzhen matt strong technology co. LTD. with dozens key words related ＂head pain secondary neurons＂. After multiple process of retrieval-reading-retrieve-reading, all the articles about head pain secondary neurons were selected. The anatomy, physiology, pathology, embryos, clinical research about the head nociceptive second-order neurons were summarized, and the role of trigeminocervical complex （TCC） in physiological and pathological conditions were analysed. Results TCC is a common neuron of all kinds of cephalalgia as the nociceptive second-order neurons. It plays an important role in the occurrence and development of cephalalgia, especially its chronification process by convergence afferents, convergence activation and convergence sensitization. Conclusions TCC is one of the most important targets in the treatment of cephalalgia at present, and its further study is very necessary.

关 键 词：头痛 神经元 痛觉 三叉颈核复合体 会聚传入 中枢敏化 

分 类 号：R322[医药卫生—人体解剖和组织胚胎学] R651[医药卫生—基础医学]