甲状腺激素对小鼠脑β-肾上腺素能受体的影响  

THE EFFECTS OF THYROID HORMONES ON β-ADRENO-CEPTOR NUMBERS IN MOUSE BRAIN

作　　者：张小莉[1] 董建英[1] 徐亚利[1] 李子瑜[1] 

机构地区：[1]江西医学院生理教研室,南昌330006

出　　处：《中国药理学通报》1991年第5期389-391,共3页Chinese Pharmacological Bulletin

摘　　要：甲状腺激素可通过调节外周组织β受体的数量,从而影响交感神经的活动。为证实甲状腺激素对中枢神经系统的影响是否也与β受体的变化有关,我们用注射T_3的方法使小鼠体内甲状腺激素增高(甲高),用放射配基结合分析法测定甲高小鼠脑β受体最大结合容量(B_(max))和亲和力(KD)的变化,并以滋阴药进行实验性治疗。结果表明:甲高小鼠脑组织β受体B_(max)较对照组显著增加(P<0.001),KD无明显变化。滋阴药生地可使甲高时升高的β受体结合位点数下降(P<0.001)。Thyroid hormones are known to influence the activities of sympathetic nerve by modifying the P-adrenoceptor numbers in several peripheral organs. In order to find out whether similar changes exist in central nervous system ( CNS ) , the changes of α-adrenergic re-cetors in mouse brain during experimental hyperthyroidism and the effects of some Yin Tonice( Rehmannia ) on that were investigated by method of radioligand binding. The results were as follows: 1 . The maximum Binding capacity (Bmax ) value of hyperthyroid mouse brain was 29% higher than the control's. No significant difference in KD value between the control and hyperthyroid animals was found . 2. By administration of rehmannia, the Bmax of hyperthyroid mouse was reduced to control value.

关 键 词：甲状腺激素 Β-肾上腺素能受体 生地 放射配基结合分析法 

分 类 号：R966[医药卫生—药理学]