龙牙楤木总甙对变态反应的影响  

Effect of aralosides on allergic reaction

作　　者：周重楚[1] 孙晓波[1] 高洪波[1] 刘威[1] 李文亭[2] 师海波[1] 金春花[1] 

机构地区：[1]吉林省中医中药研究院中药研究所药理室,长春130021 [2]长春中医学院

出　　处：《中国药理学与毒理学杂志》1991年第1期34-37,共4页Chinese Journal of Pharmacology and Toxicology

摘　　要：龙牙楤木总甙(As)显著抑制PCA反应、Porssman皮肤血管炎、大鼠迟发型皮肤超敏反应、佐剂关节炎、Arthus反应、反向被动Arthus反应。但攻击前ig As对PCA反应,致敏前后ig As对Arthus反应和对Arthus反应大鼠血清中免疫复合物均无明显影响。Aralosides inhibited significantly PCA reaction when it was administered ig before and after sensitization. Some suppressive effect on PCA reaction was shown when it was given ig before challenge, however, the difference between the two groups of rats was not significant statistically. It had marked suppressive effect on Forssman cutaneous vasculitis, and the adjuvant arthritis. The delayed type hypersensitivity reaction induced by tuberculin in rats was distinctly suppressed by administration of aralosides both before and after sensitization as well as the challenge, however, the suppressive effect was moremarked when administration of aralosides was before and after challenge than before and after sensitization. When aralosides was given ig administered before and after sensitization it had no apparent effect upon Arthus reaction, however, when it was administered before challenge Arthus reaction was noticeably inhibited. It had significant suppressive effect on reversible passive Arthus reaction. Aralosides had no effect on the content of immune complex in serum of rats with Arthus reaction.

关 键 词：变态反应 

分 类 号：R282.710.5[医药卫生—中药学]