绝经后女性唾液皮质醇水平与代谢综合征的相关性研究  

Correlation between salivary cortisol levels and metabolic syndrome in postmenopausal women

作　　者：辛本勤 田玉峰[2] 董彦军[2] 

机构地区：[1]日照市中心血站检验科,山东276826 [2]日照市人民医院

出　　处：《社区医学杂志》2017年第18期24-26,共3页Journal Of Community Medicine

摘　　要：目的探讨绝经后女性唾液皮质醇水平与代谢综合征(metabolicsyndrome,MS)的关系。方法 2014年8月—2016年5月,选取120例绝经后女性MS患者作为MS组,另选110例绝经后健康女性作为对照组,进行血压、身高、体质量测量,计算体重指数(body mass index,BMI)。检测两组唾液皮质醇以及血清三酰甘油(triglyceride,TG)、胆固醇(cholesterol,TC)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDLC)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDLC)、空腹血糖(fasting blood glucose,FBG)及空腹胰岛素(fasting insulin,FINS)水平,用稳态模型评估法(homeostatic model assessment,HOMA)来评价胰岛素抵抗指数(HOMA-IR)。计量资料采用t检验,相关分析采用Pearson相关分析,P<0.05为差异有统计学意义。结果 MS组唾液皮质醇水平、BMI、收缩压、FBG、TG、FINS、HOMA-IR水平分别为(12.21±5.72)mmol/L、(26.6±2.2)kg/m2、(129±10)mm Hg(1 mm Hg=0.133k Pa)、(6.31±1.32)、(2.12±1.20)mmol/L、(57.2±26.7)pmol/L、(5.36±1.41),均显著高于对照组的(10.33±3.54)mmol/L、(22.6±1.6)kg/m2、(114±7)mm Hg、(5.1±0.4)、(1.57±0.83)mmol/L、(43.9±22.1)pmol/L、(2.59±1.08),差异均有统计学意义(均P<0.05)。MS组HDL-C水平为(1.35±0.34)mmol/L,明显低于对照组的(1.64±0.25)mmol/L,差异有统计学意义(P<0.05)。MS组唾液皮质醇与BMI、舒张压、TG、FINS及HOMA-IR呈正显著相关(r=0.695、0.412、0.649、0.706、0.587、0.352),与HDL-C呈显著负相关(r=-0.614)。结论绝经后女性唾液皮质醇水平与MS呈正相关。Objective To observe the relationships between salivary cortisol levels and metabolic syndrome in postmenopausal women. Methods From August 2014 to May 2016, a total of 120 cases of postmenopausal women with the metabolic syndrome patients were selected as group MS and 110 healthy women after menopause as control group. Blood pressure, height and body mass,were measured and body mass index was calculated. Saliva cortisol and serum triglyceride, cholesterol, low-density lipoprotein cholesterol, high density lipoprotein cholesterol, fasting blood glucose and fasting insulin were detected and to evaluate the insulin resistance index（HOMA-IR） with the HOMA steady state model. Results The levels of saliva cortisol,BMI,systolic pressure, FBS, TG, FINS and HOMA-IR in the MS group were（12.21±5.72）mmol/L,（26.6±2.2）kg/m2,（129±10）mm Hg,（6.31±1.32）,（2.12±1.20）mmol/L,（57.2±26.7）pmol/L,（5.36±1.41）,were all significantly higher than the control group[（10.33±3.54）mmol/L,（22.6±1.6）kg/m2,（114±7）mm Hg,（5.1±0.4）,（1.57±0.83）mmol/L,（43.9±22.1）pmol/L,（2.59±1.08）], while HDL-C in the MS group was（1.35±0.34）mmol/L and significantly lower than in control group[（1.64±0.25）mmol/L], the differences were all statistically significant（all P〈0.05）. The level of salivary cortisol in the MS group were positively correlated with BMI, diastolic pressur, TG, FINS and HOMA-IR（r=0.695,0.412,0.649,0.706,0.587,0.352）, negatively correlated with HDL-C（r=-0.614）.Conclusion Salivary cortisol levels were positively related to metabolic syndrome in postmenopausal women.

关 键 词：绝经 代谢综合征 唾液皮质醇 

分 类 号：R588.6[医药卫生—内分泌]