基因印迹在特应性皮炎和银屑病发病中的作用  

Effects of Genomic Imprinting in Atopic Dermatitis and Psoriasis

作　　者：邢飞 何晓蕾[1] 雷铁池[1] 

机构地区：[1]武汉大学人民医院皮肤科,武汉430060

出　　处：《医学综述》2017年第22期4397-4402,共6页Medical Recapitulate

摘　　要：基因依赖单亲传递遗传信息的现象称为基因印迹,出现印迹遗传的基因称为印迹基因。其本质是染色质的表观遗传学修饰,即DNA的表观遗传变异。DNA的甲基化或组蛋白的甲基化目前被认为是导致印迹等位基因沉默的主要原因。人类许多疾病的发生与基因印迹有关。但目前有关基因印迹与特应性皮炎和银屑病(包括银屑病型关节炎)发病的研究并不多,主要集中于DNA甲基化、组蛋白修饰、染色质重构和非编码RNA,且着重于单个或几个相关基因的研究。未来,随着全基因组基因芯片平台技术的发展和高通量测序技术的应用,基因印迹在特应性皮炎和银屑病发病中的作用将被进一步阐明。The phenomenon that only one allele of a particular gene is expressed in a parent-of-origin dependent manner is called genomic imprinting, and the genes are called imprinting genes. Its essence is the epigenetic modification of ehromatin, namely the epigenetie changes of DNA. Currently, DNA methylation and histone methylation are considered to be the main cause of imprinted allele gene silence. Many human diseases are related to genetic imprinting. But now the studies of genomie imprinting related to atopic dermatitis and psoriasis （ including psoriatic arthritis ） are not much, which are mainly concentrated in DNA methylation, histone modification, chromatin remodeling, and non-coding RNA, and focused on a single or several related genes. In the future, with the development of genome-wide genechip platform technology and application of high-throughput sequencing, the effects of genomic imprinting in atopic dermatitis and psoriasis will be further elucidated.

关 键 词：基因印迹 特应性皮炎 银屑病 银屑病型关节炎 

分 类 号：R758.2[医药卫生—皮肤病学与性病学] R758.63[医药卫生—临床医学]