机构地区:[1]安徽医科大学九十八临床学院,解放军第九十八医院神经外二科,湖州313000
出 处:《中华创伤杂志》2017年第11期984-989,共6页Chinese Journal of Trauma
基 金:南京军区医学科技创新基金(11Z002)
摘 要:目的探讨有创颅内压联合经颅多普勒(TCD)监测在创伤性急性弥漫性脑肿胀(PADBS)救治中的作用及其对脑功能的保护作用。方法采用回顾性病例对照研究分析2014年1月-2016年1月收治的120例PADBS患者临床资料,其中男88例,女32例;年龄19~70岁,平均43.6岁。120例患者根据是否行颅内压监测及监测方式分为三组,其中未行颅内压监测(A组)37例,仅行有创颅内压监测(B组)40例,有创颅内压联合TCD监测(C组)43例。比较三组患者ICU住院时间、伤后12个月预后较好率[格拉斯哥预后评分(GOS)4~5分]、巴塞尔指数(BI)、简易精神状态评价(MMSE)。比较三组中手术患者入院至术前瞳孔变化率、GCS下降值。结果(1)A、B、C组患者ICU住院时间分别为(9.6±6.8)d、(9.2±5.4)d、(8.9±5.7)d(P〉0.05),A、B、C组预后较好率分别为46%(17/37)、65%(26/40)、72%(31/43)(P〈0.05),B组和C组高于A组(P〈0.05),但B组与C组差异无统计学意义(P〉0.05)。A组BI、MMSE分别为(51.0±36.7)分、(17.3±12.5)分,B组分别为(58.0±35.7)分、(18.8±12.0)分,C组分别为(70.2±34.6)分、(21.2±11.4)分(P〈0.05);B组和C组均高于A组(P〈0.05),而B组均低于C组(P〈0.05)。(2)A、B、C组手术患者入院至术前瞳孔变化率分别为33%(9/27)、13%(4/30)、7%(2/28)(P〈0.05),B组和C组低于A组(P〈0.05),但B组与C组差异无统计学意义(P〉0.05)。A、B、C组手术患者入院至术前GCS下降值分别为(1.4±1.3)分、(0.7±0.5)分、(0.6±0.4)分(P〈0.05),B组和C组低于A组(P〈0.05),但B组与C组差异无统计学意义(P〉0.05)。结论有创颅内压联合TCD监测,能精准、及时监测PADBS患者的病情变化,提高患者的预后Objective To investigate the combined effects of invasive intraeranial pressure and transcranial Doppler (TCD) monitoring in the treatment for posttraumatic acute diffuse brain swelling (PADBS). Methods The clinical data of 120 patients with PADBS admitted from January 2014 to January 2016 were retrospectively analyzed by case-control study. There were 88 males and 32 females, aged 19-70 years (mean, 43.6 years). Patients were divided into three groups based on whether they had accepted invasive intracranial pressure and TCD: Group A (37 cases) with neither invasive intracranial pressure nor TCD, Group B (40 cases) with invasive intracranial pressure only, and Group C (43 cases) with both intracranial pressure and TCD. The hospitalization time in ICU, better prognosis [ Glasgow outcome scale (GOS) scored 4-5 ] at 12 months after injury, Barthel index ( BI), and mini-mental status examination (MMSE), mydriasis rate, and decreased values of Glasgow coma scale (GCS) were compared among three groups. Results ( 1 ) The ICU length of stay in the Groups of A, B and C was respective (9.6 ± 6.8) days, (9.2 ±5.4) days and (8.9± 5.7 ) days (P 〉 0.05 ). The ratio of better prognosis in the Groups of A, B and C was respective 46% (17/37) , 65% (26/40) and 72% (31/43) , showing a better result in Groups B and C than Group A (P 〈 0.05). However, there was no significant difference in ratio of better prognosis between Groups B and C ( P 〉 0.05 ). The BI in the Groups of A, B and C was respective (51.0 ±36.7) points, (58.0 ±35.7 ) points and (70.2± 34.6) points, while the MMSE was respective ( 17.3 ± 12.5 ) points, ( 18.8 ± 12.0) points and (21.2 ± 11.4) points. Both BI and MMSE in Groups B and C were higher than those in Group A (P 〈0.05), moreover, those in Group B were also statistically lower than those in Group C ( P 〈 0. 05 ). ( 2 ) Tile ratio of mydriasis from admission to initiation of o
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