厄贝沙坦联合黄葵胶囊治疗慢性肾小球肾炎的效果观察  

Effect observation of Irbesartan combined with Huangkui Capsule on treating chronic glomerulonephritis

作　　者：金碧辉[1] 杨立宏[1] 

机构地区：[1]内蒙古赤峰市医院肾脏内科,内蒙古赤峰024000

出　　处：《中国当代医药》2017年第30期89-91,共3页China Modern Medicine

摘　　要：目的探讨厄贝沙坦联合黄葵胶囊治疗慢性肾小球肾炎的疗效。方法选取2016年1月~2017年1月我院收治的40例慢性肾小球肾炎患者作为研究对象,根据治疗方法将其分为对照组与观察组,每组各20例。对照组患者采用厄贝沙坦治疗,观察组患者采用厄贝沙坦联合黄葵胶囊治疗,比较两组患者的临床效果。结果治疗前,两组患者的24 h蛋白尿和血肌酐比较,差异无统计学意义(P>0.05)。治疗后,观察组患者的24 h蛋白尿[(0.82±0.24)g]和血肌酐[(80.01±8.03)μmol/L]低于对照组[(1.02±0.32)g,(83.52±10.11)μmol/L],差异均有统计学意义(P<0.05)。治疗后观察组患者的24 h蛋白尿、血肌酐水平低于治疗前,差异有统计学意义(P<0.05)。观察组患者的治疗总有效率(90.0%)高于对照组(70.0%),差异有统计学意义(P<0.05)。两组患者的不良反应发生情况比较,差异无统计学意义(P>0.05)。结论厄贝沙坦联合黄葵胶囊治疗慢性肾小球肾炎的临床疗效良好,值得临床推广与应用。Objective To investigate the efficacy of Irbesartan combined with Huangkui Capsule in the treatment of chronic glomerulonephritis.Methods From January 2016 to January 2017,40 patients with chronic glomerulonephritis treated in our hospital were selected as objects.According to the different therapeutic methods,they were divided into control group and observation group,20 cases in esch group.In the control group,patients were treated with lrbesartan only,while in the observation group,Huangkui Capsule was added.The clinical efficacy in the two groups was compared. Results Before treatment,there was no significant difference in 24-hour proteinuria or serum creatinine （P〉0.05）.After treatment, in the observation group [（0.82±0.24） g,（80.01 ±8.03）μmol/L] were lower than the observation group [（1.02±0.32） g,（83.52±10.11） μmol/L],and the differences were statistically significant （P〈0.05）. After treatment,the 24-hour proteinuria and serum creatinine levels were lower than before treatment,and the differences were statistically significant （P〈0.05）.The total effective treatment rate in the observation group （90.0%） was higher than that in the control group （70.0%）,and the difference was statistically significant （P〈0.05）.There was no significant difference in adverse reactions between the two groups （P〉0.05）.Conclusion Irbesartan combined with Huangkui Capsule can obtain a great effect on treating chronic glomerulonephritis,which is worthy of clinical application and promotion.

关 键 词：厄贝沙坦 黄葵胶囊 慢性肾小球肾炎 临床疗效 

分 类 号：R692.31[医药卫生—泌尿科学]