血浆D-二聚体及凝血四项检测在妊娠高血压综合征中的价值  

Value of plasma D-dimer and coagulation four markers in pregnancy-induced hypertension syndrome

作　　者：梁福笑[1] 方运勇[1] 文海平[1] 曾岳新 

机构地区：[1]广东省东莞市妇幼保健院产前诊断中心,广东东莞523000

出　　处：《中国当代医药》2017年第30期126-128,132,共4页China Modern Medicine

基　　金：广东省东莞市医疗卫生一般项目(2016105101074)

摘　　要：目的探讨血浆D-二聚体(D-D)及凝血四项检测在妊娠期高血压综合征孕妇中的应用价值。方法采用回顾性分析的方法分析2015年1月~2016年6月在本院诊断为妊娠期高血压综合征的87例孕妇(妊娠高血压综合征组)、30例正常孕妇(正常妊娠组)及30例未孕妇女(正常对照组)的资料,比较各组的凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)、D-D水平。结果妊娠高血压综合征组的PT、APTT明显短于正常妊娠组和正常对照组,FIB、D-D水平明显高于正常妊娠组和正常对照组,差异有统计学意义(P<0.05)。正常妊娠组的PT、APTT明显短于正常对照组,FIB、D-D水平明显高于正常对照组,差异有统计学意义(P<0.05)。三组的TT水平比较,差异无统计学意义(P>0.05)。结论妊娠期妇女的血液处于高凝状态,尤其是妊娠高血压综合征妇女,因此常规检查凝血功能和D-D有助于了解妊娠高血压综合征妇女的凝血及纤溶功能情况,对辅助妊娠期高血压综合征的诊断、病情观察、治疗及预防其并发症具有重要临床意义。Objective To investigate the value of plasma D-dimer （D-D） and coagulation four markers in pregnant women with pregnancy-induced hypertension syndrome.Methods A retrospective analysis was carried out on 30 cases of normal pregnant women （the normal pregnancy group）,30 cases of non-pregnant women （the normal control group） and 87 cases of pregnant women who were diagnosed as pregnancy-induced hypertension syndrome （the pregnancy-induced hypertension group） in our hospital from January 2015 to June 2016.The level of prothrombin time （PT）,activated partial thromboplastin time （APTT）,thrombin time （TT）,fibrinogen （FIB） and D-D level were compared.Results The PT and APTT of the pregnancy-induced hypertension group was significantly shorter than that of the normal pregnancy group and the normal control group,and the level of FIB and D-D of the pregnancy-induced hypertension group was significantly higher than that of the normal pregnancy group and the normal control group,with significant difference （P〈0.05）. The PT and APTT of the normal pregnancy group was significantly shorter than that of the normal control group,and the level of FIB and D-D of the normal pregnancy group was significantly higher than that of the the normal control group, with significant difference （P〈0.05）.There was no statistical difference between the TI＂ of the three groups （P〉0.05）. Conclusion The blood of pregnant women is in hypercoagulable state,especially in pregnancy-induced hypertension women.Therefore,the routine examination of blood coagulation and D-D eontributes to the understanding the coagulation and fibrinolysis function of pregnaney-induced hypertension women.h has important clinical significance in the diagnosis,observation,treatment and prevention of complications of pregnancy-indueed hypertension syndrome.

关 键 词：妊娠 高血压 高凝状态 

分 类 号：R714.246[医药卫生—妇产科学]