健脾补肾法联合夫精宫腔内人工授精治疗非严重弱精子症不育的研究  

Study on the treatment with the method of invigorating spleen and tonifying kidney combined with intrauterine insemination in male infertility with non severe asthenospermia

作　　者：张淑婷[1,2] 周少虎[1] 翁治委[1] 梁爱军[1] 彭新良 余丽[1] 刘立[1] 谢建兴[1] 

机构地区：[1]广州中医药大学第一附属医院,广东广州510405 [2]广州中医药大学,广东广州510405

出　　处：《现代中西医结合杂志》2017年第33期3649-3652,3667,3668,共6页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：广东省中医药管理局资助项目(20151234);广东省科学计划项目(20140213)

摘　　要：目的探讨健脾补肾法对非严重弱精子症不育患者精子质量相关指标及其配偶夫精宫腔内人工授精(IUI)后妊娠结局的影响。方法将脾肾两虚型拟行IUI的60例不育男性患者随机分为健脾补肾法组和空白组,每组30例。健脾补肾法组给予健脾补肾中药口服12周,空白组不给予任何药物干预。2组分别于入组时和入组12周后行算机辅助精液分析(CASA)和精子形态学、精子DNA完整性检测,并追踪随访患者配偶IUI后的妊娠结局。结果治疗12周后,健脾补肾法组患者精子活力和前向运动精子率均明显高于治疗前(P均<0.05);2组入组时和入组12周后精液量、精子浓度、精子形态、精子DNA完整性以及精子运动参数比较差异均无统计学意义(P均>0.05);随访健脾补肾法组临床妊娠率、累积妊娠率和活胎率有高于空白组的趋势,但差异均无统计学意义(P均>0.05)。结论健脾补肾法能提高非严重弱精子症不育患者的精子活力和前向运动精子率,有助于改善IUI的妊娠结局。Objective It is to investigate the influence of invigorating spleen and tonifying kidney on sperm quality related indicators of male infertility patients with non severe asthenospermia and pregnancy outcomes in their spouses after intrauterine insemination(IUI) by husband. Methods A total of 60 male infertility patients with spleen and kidney deficiency type were collected and randomly divided into two groups with 30 cases in each. The patients were treated by oral administration with Chinese medicine of invigorating spleen and tonifying kidney in Group A,12 weeks for one course of treatment,but did not receive any intervention in Group B. Before and after treatment,the changes of sperm quality indexes were detected by computer assisted sperm analysis(CASA),sperm morphology and sperm DNA integrity detection,and the pregnancy outcome in their spouses after IUI was followed up. Results After treatment of 12 weeks,the sperm motility and forward motile sperm ratio were significantly higher compared with before treatment in Group A(P < 0. 05); there was no significant difference in semen volume,sperm concentration,sperm morphology,sperm DNA integrity and sperm motility parameters before and after treatment in the two groups(all P < 0. 05); the clinical pregnancy rate and cumulative pregnancy rate and live birth rate of Group A were more higher than those of B group,but there was no significantly difference(P > 0. 05). Conclusion The method of invigorating spleen and tonifying kidney combined with IUI in the treatment of male patients with non severe asthenospermia can improve the sperm motility and forward movement speed,and it can also improve the pregnancy outcome of IUI.

关 键 词：健脾补肾法 男性不育 弱精子症 人工授精 

分 类 号：R321-33[医药卫生—人体解剖和组织胚胎学]