囊胚发育速度和质量对复苏周期妊娠结局及新生儿出生情况的影响  

Influence of blastocysts morphological score on pregnancy outcomes and neonate′s condition in vitrified-warmed transfer cycles

作　　者：孟庆霞[1] 郑爱燕[1] 丁洁[1] 蒲艳[1] 廖桂芝 李红[1] 王玮[1] 

机构地区：[1]南京医科大学附属苏州医院苏州市立医院生殖与遗传中心,215002

出　　处：《实用医学杂志》2017年第21期3585-3589,共5页The Journal of Practical Medicine

基　　金：江苏省苏州市卫生局项目(编号:lczx201411);江苏省苏州市临床医学中心项目(编号:szzx201505)

摘　　要：目的研究囊胚发育速度和囊胚评分对复苏周期妊娠结局及新生儿出生情况的影响。方法回顾性分析2010年3月至2016年2月586个复苏周期单囊胚移植患者的临床资料,观察囊胚发育时间、内细胞团(ICM)评分和滋养层细胞(TE)评分对玻璃化冷冻复苏周期妊娠结局及新生儿出生情况的影响。结果囊胚发育时间,ICM评分和TE评分对临床妊娠率、新生儿出生体质量和新生儿性别比均无显著影响(P>0.05);囊胚发育时间和ICM评分对流产率有显著影响(P<0.05),是影响流产率的两个主要指标;囊胚发育时间、ICM评分和TE评分对活产率均有显著影响(P<0.05),且TE评分是影响活产率的首要因素。结论挑选发育第5天内细胞团质量和滋养层细胞质量高的胚胎可以获得高活产率和低流产率,但是这些指标并不能预测新生儿出生体重和新生儿出生性别比。Objective To estimate the effect of blastocysts morphological score on pregnancy outcomesand neonate′s condition in vitrified-warmed single-blastocyst transfer cycles. Methods A retrospective analysis of586 cycles of vitrified-warmed single-blastocyst transfer from Mar. 2010 to Feb. 2016 was performed and the influ-ence of day of vitrification,inner cell mass(ICM)and trophectoderm(TE)scores on pregnancy outcomes and neo-nate′s condition were observed. Results There were no significant differences in clinical pregnancy rate,birthweight and sex ration of newborn between different vitrification day,ICM score and TE score. The day of vitrifica-tion and ICM score can significantly influence pregnancy loss rate,and were the two primary predictors of pregnan-cy loss rate. Vitrification day,ICM score and TE score exerted significant influence on live birth rate(P < 0.05)and TE score was the primary factor of live birth rate. Conclusions Day 5 vitrified blastocysts with higher qualityof ICM and TE can provide high live birth rate and low pregnancy loss rate,but it could not predict the weight andgender of the newborn.

关 键 词：单囊胚移植 囊胚评分 妊娠结局 新生儿 

分 类 号：R714.8[医药卫生—妇产科学]