海兰地嗪对血小板聚集的影响及机理探讨  

Effect of hernandezine on platelet aggregation and its mechanism of action

作　　者：马丽娟[1] 尹钟洙[1] 刘干中[1] 

机构地区：[1]中日友好医院临床医学研究所药物药理室,北京100029

出　　处：《中国药理学与毒理学杂志》1991年第1期41-43,共3页Chinese Journal of Pharmacology and Toxicology

摘　　要：海兰地嗪(Her)体外对胶原,ADP,A23187和AA诱导的大鼠血小板聚集有明显抑制作用,其IC_(50)分别为14.5,41.6,44.1和48.3μg/ml。Her对AA诱导的大鼠血小板MDA生成不能抑制,但能升高兔血小板cAMP水平和抑制凝血酶诱导的人血小板胞浆内游离钙离子浓度升高。Her的抗血小板聚集作用机理可能与升高血小板内cAMP水平和抑制细胞内游离钙离子浓度升高有关。Hernandezine, an isoquinoline alkaloid, is one of the active ingredients isolated from Thalictrum glandulosissimum. It was found to inhibit markedly rat platelet aggregation induced by collagen, ADP, calicimycin (A-23187) and arachidonic acid (AA) in vitro. The IC50 were 14.5, 41.6, 44.1 and 48.3μg/ml, respectively. Hernandezine (25, 50 and 100 μg / ml) could not inhibit the formation of MDA in-duced by AA. Hernandezine could increase the concentration of cAMP in rabbit platelet and inhibit the increase of the cytosolic free Ca2+ concentration in human platelet induced by thrombin.

关 键 词：海兰地嗪 血小板 金丝马尾莲 药理 

分 类 号：R282.710.5[医药卫生—中药学]