骨血管生成机制与功能的研究进展  

Systemic review of mechanism and function of bone vascularization

作　　者：董晤讯 袁翰[1] 马勇[1] 郭杨[1] 苑文超 李广广[1] 黄桂成[1] 

机构地区：[1]南京中医药大学骨伤修复与重建新技术实验室,江苏南京210023

出　　处：《中国现代医学杂志》2017年第27期51-58,共8页China Journal of Modern Medicine

基　　金：江苏省高校研究生科研创新计划项目(No:KYZZ16_0409);江苏省金坛市科研计划项目(No:JT2013070)

摘　　要：骨骼是高度血管化的组织,依赖于血管和骨细胞之间的密切关系,以维持骨骼完整性。因此,血管生成在骨骼发育、修复和重塑中起关键作用。骨血管是为骨细胞传递氧、营养素、激素、神经递质和生长因子等的主要通道,骨血管还参与协调造血过程。骨毛细血管可以区分出两种亚型,包括位于干骺端的H型和在骨干的骨髓腔中形成毛细管网的L型。已有研究表明,血管生成和骨形成的过程是偶联的,这其中涉及多种细胞因子、信号通路及micro RNA的参与。该研究回顾关于骨血管的结构、功能和相关调节因素的最新数据,特别强调血管生成和血管功能在骨发育和再生中的作用及其在骨折愈合和骨组织工程中的应用。The bone is a highly vascularized organ which depends on intimate connection between bloodvessels and cells to maintain its integrity. Thus, angiogenesis plays a pivotal role in development, repair andremodeling of bone. Blood vessel is the main channel for the transmission of oxygen, nutrients, hormones,neurotransmitters and growth factors for bone cells. Vessels are also involved in coordinating the hematopoiesisprocedure. There are 2 subtypes of capillaries in bone, including H-type located in the metaphyseal and L-type in the backbone of the bone marrow cavity. Studies have shown that angiogenesis is closely associatedwith bone formation requiring cytokines, MicroRNA and other signaling pathways. In this paper, we reviewedthe latest publications on the structure, function and related regulatory factors of bone vessels. Morespecifically, we emphasize on the role of angiogenesis and vascular function in development and regenerationof bone, which may provide therapeutic approaches in fracture healing and bone engineering.

关 键 词：血管生成 骨形成 内皮细胞 成骨细胞 软骨细胞 MICRORNA 

分 类 号：R681[医药卫生—骨科学]