桉柠蒎肠溶软胶囊预防儿童急性中耳炎鼓室积液的效果研究  

The Clinical Application of Eucalyptol,Limonene and Pinene Enteric Soft Capsules in the Treatment of the Prophylaxis of Tympanum Fluid in Secretory Otitis Media in Children

作　　者：张欣然[1] 马琳[1] 金燕[1] 林芳竹 张庆丰[1] 

机构地区：[1]大连市中心医院耳鼻咽喉头颈外科,大连116033

出　　处：《听力学及言语疾病杂志》2017年第6期607-609,共3页Journal of Audiology and Speech Pathology

摘　　要：目的观察桉柠蒎肠溶软胶囊预防儿童急性中耳炎鼓室积液的效果。方法 2013年4月至2016年9月发病48小时内就诊的341例(497耳)6~12岁儿童急性中耳炎(非化脓性)患儿随机分为实验组(172例46耳)和对照组(169例251耳),对照组给予1%苯酚甘油滴耳,糠酸莫米松喷鼻剂喷鼻,每日一次,实验组在同对照组治疗基础上口服桉柠蒎肠溶软胶囊半个月;于发病第7日和第14日复诊,比较两组症状和体征变化,对照组7日复诊时明确鼓室积液的患儿加用桉柠蒎肠溶软胶囊。结果7日复诊时对照组发生鼓室积液110例(170耳)(65.09%,110/169),实验组发生鼓室积液51例(70耳)(29.65%,51/172),前者高于后者(P<0.01);14日复诊时,对照组仍有鼓室积液41例(66耳)(24.26%,41/169),实验组鼓室积液32例(36耳)(18.60%,32/172),前者高于后者(P<0.05)。14日复诊时对照组7日复诊确诊为鼓室积液的110患儿中规律服药的75例患儿中鼓室积液消失54例(60耳)(72.0%,54/75),未规律服药的35例患儿中鼓室积液消失15例(22耳)(42.86%,15/35),差异有统计学意义(P<0.01)。结论儿童急性中耳炎患者发病后口服桉柠蒎肠溶软胶囊能够有效降低鼓室积液的发生率,发生鼓室积液后加用该药可促进积液的排出。Objective To investigate the effects of the eucalyptol,limonene and pinene enteric soft capsules(mucoregulatory agents)in preventing from tympanum fluid in children.Methods A total of 341 children(497 ears)with acute otitis media were randomly divided into two groups:the experimental group and the control group.The experimental group was given symptomatic treatment and oral in-take of the eucalyptol,limonene and pinene enteric soft capsules,while the control group with acute otitis media received conventional symptomatic treatment.All the patients were followed-up 7 and 14 days after treatment.Clinical data were collected,including symptoms,and tympanogram changes.Results Seven days after the initial treatment,tympanum fluid occurred in 110 cases of170 ears(65.09%,110/170)in the control group,and in 51 cases of 70 ears(29.65%,51/172)in the experimental group.The difference was statistically significant(P<0.01).After 14 days,41 cases(66 ears)of tympanum fluid occurred in the control group(24.26%,41/169),32 cases(36 ears)of otitis media(18.60%,32/172)occurred in the experimental group.The difference was statistically significant(P<0.01).In the control group,the tympanum fluid disappeared in 54 cases(60 ears)after regular treatment 72.0%,54/75),and reliefed in 15 cases(22 ears)with irregular treatment(42.86%,15/35).The difference was statistically significant(P<0.01).Conclusion Eucalyptol,limonene and pinene enteric soft capsules can effectively reduce the incidence of tympanum fluid in children with acute otitis media.Mucoregulatory agents may promote the eduction of effusion.

关 键 词：黏液调节剂 儿童 急性中耳炎 鼓室积液 

分 类 号：R764.2[医药卫生—耳鼻咽喉科]