声治疗与药物治疗慢性耳鸣疗效的Meta分析  

The Efficacy of Sound Therapy and Conventional Medical Treatment in the Treatment of Chronic Tinnitus:A Meta-analysis

作　　者：江洋[1] 华清泉[1] 杨琨[1] 任杰[1] 曾峰 盛建飞[1] 张志坚[1] 管红霞 

机构地区：[1]武汉大学人民医院耳鼻咽喉头颈外科,武汉430060 [2]湖北省妇幼保健院耳鼻咽喉科

出　　处：《听力学及言语疾病杂志》2017年第6期651-655,共5页Journal of Audiology and Speech Pathology

基　　金：国家自然科学基金面上项目(81271073);湖北省自然科学基金(2016CFB661)资助

摘　　要：目的比较单纯声治疗与药物治疗慢性耳鸣的疗效。方法通过计算机检索中国期刊全文数据库(CNKI)、万方数据库、维普数据库(VIP)、中国生物医学文献数据库(CBM)、Pubmed、Embase、OVID、SciVerse ScienceDirect和Cochrane library从建库到2017年5月与耳鸣治疗相关文献,按照纳入和排出标准进行筛选,并对其进行严格质量评价和资料提取,采用Revman 5.2软件对纳入文献的总有效率、耳鸣障碍量表(tinnitus handicap inventory,THI)分值和视觉模拟量表(visual analogue scale,VAS)分值进行Meta分析。结果共纳入符合要求的文献16篇,其中,中文文献14篇,英文文献2篇,共计1 594例患者;声治疗组总有效率分别为86.42%(按例数)和80.50%(按耳数),药物治疗组总有效率分别为60.62%(按例数)、48.10%(按耳数),差异均有统计学意义[P<0.01(按例数);P<0.01(按耳数)]。治疗后声治疗的THI值比治疗前明显下降,且较药物治疗降低更明显(P<0.01),治疗后声治疗的VAS值较治疗前明显下降,且较药物治疗降低更明显(P<0.05)。结论与药物治疗相比,声治疗能明显提高耳鸣疗效,减轻耳鸣患者症状。Objective To compare the efficacy of sound therapy and conventional medical treatment in the treatment of chronic tinnitus.Methods CNKI,Wanfang database,Weipu database(VIP),Chinese biomedical literature database(CBM),Pubmed,Embase,OVID,SciVerse ScienceDirect and Cochrane library were used.The data were retrieved up to May 2017,and the relevant literature was screened according to the inclusion and emission standards.The quality of the literatures were analyzed and the data was extracted.Meta analysis was carried out by using Revman 5.2 software with total effective rate,tinnitus handicap inventory(THI)value and visual analogue scale(VAS)value.Results A total of 16 articles(1 594 patients)were included in the literature,including 14 articles in Chinese and 2 articles in English.The total effective rate in the sound therapy group were 86.42%(by patients)and 80.50%(by ears),while in conventional medical treatment group were 60.62%(by patients),and48.10%(by ear),respectively[P<0.01(by patients),P<0.01(by ear)].The changes of THI value were analyzed before and after treatment,the difference was statistically significant(P<0.01).The changes of VAS value were analyzed before and after treatment,the difference was statistically significant(P<0.05).Conclusion Compared with conventional medical treatment,sound therapy can significantly improve the clinical efficacy of tinnitus treatment and reduce the symptoms in tinnitus patients.

关 键 词：耳鸣 声治疗 药物治疗 META分析 

分 类 号：R764.45[医药卫生—耳鼻咽喉科]