葡萄糖糖化血红蛋白与纤维蛋白原检测在2型糖尿病眼部微血管病变中的应用价值  

Application value of glycosylated hemoglobin and fibrinogen in the intraretinal microvascular lesions of type 2 diabetes mellitus

作　　者：霍晓丽[1] 姚怀娟 潘琳琳[1] 王海洋[1] 陆玉军 付怀栋[1] Xiaoli HUO;Huaijuan YAO;Linin PAN;Haiyang WANG;Yujun LU;Huaidong FU＊(Department of Internal Medicine, Guanyun County People＇s Hospital of Lianyungang City, Lianyungang 222000, Chin)

机构地区：[1]连云港市灌云县人民医院内科,江苏连云港222000

出　　处：《临床检验杂志（电子版）》2017年第3期448-449,共2页Clinical Laboratory Journal(Electronic Edition)

摘　　要：目的探讨糖化血红蛋白(HbA1c)联合纤维蛋白原(FIB)检测在2型糖尿病(T2DM)眼部微血管病变诊断价值。方法检测T2DM合并眼部微血管病变(A组)及眼部无微血管病变患者(B组)HbA1c及FIB水平并统计学分析。结果 A组HbA1c和F1B明显高于B组,两组有统计学差异(P<0.05);A组中HbA1c及FIB呈正相关,且明显高于B组(P<0.05)。HbA1c单项检测低于两者联合检测阳性率(P<0.05)。结论联合检测HbA1c和FIB对于早期诊断和治疗T2DM合并眼部微血管病变有重要价值。Objective To investigate the diagnostic value of FIB and HbA1c in T2DM with ocular microan-giopathy. Methods According to the ocular microvascular lesion, the patients with DM were divided into two groups （group A wih microvascular lesion, group B wihout microvascular lesion）, the level of HbA1c and FIB were detected as well as statistical analysis. Results The level of HbA1c and FIB in group A was apparently higher than group B （P〈0.05）. HbA1c was positively correlated with FIB, and was apparently higher than group B （P〈0.05）. The single test of HbA1c was lower than the combined detection of positive rate （P〈0.05）. Conclusion Combined detection of HbA1c and FIB has important value in early diagnosis and treatment of T2DM with ocular microvascular lesions.

关 键 词：糖化血红蛋白 纤维蛋白原 2型糖尿病 眼 微血管病变 

分 类 号：R587.2[医药卫生—内分泌]