壳聚糖的改性及纳米粒的制备  

The Modification of Chitosan and Preparation of Nanoparticles

作　　者：宋玉品[1] 陈新新 张红豆 

机构地区：[1]石家庄学院化工学院,河北石家庄050035

出　　处：《石家庄学院学报》2017年第6期9-14,共6页Journal of Shijiazhuang University

基　　金：河北省自然科学基金(H2016106034);石家庄学院化工制药实验教学示范中心本科生科技创新基金(口服艾塞那肽纳米粒的研制)

摘　　要：研究了以3种不同分子量的壳聚糖为原料,对其进行季氨化反应合成3种不同分子量的三甲基壳聚糖,用红外光谱对三甲基壳聚糖进行定性检测,并测定其水溶性.水溶性顺序用分子量表示为70万>4万>10万.以分子量为70万的三甲基壳聚糖作为载体材料,三聚磷酸钠作为交联剂,采用离子交联法制备纳米粒.以成球率为指标,通过单因素筛选得到制备纳米粒的最优处方:三甲基壳聚糖浓度为0.4 mg/m L,三聚磷酸钠浓度为0.2 mg/m L,两者的加入体积比为3∶2.In this project, N, N, N-trimethyl （TMC） is synthesized from three kinds of chitosan with differentviscosity through quaternization reaction. The obtained TMC is characterized by FTIR. Testing its water solubility,the result shows that 70w〉4w〉10w is indicated by TMC’ s molecular weight. Subsequently, TMC nanoparticles areprepared by ionic gelation method with TPP as the cross linking agent, and characterized by the precipitation effica原cy. Single factor screening is carried out to study the best prescription composition： the concentration of TMC is 0.4mg/mL, the concentration of TPP is 0.2 mg/mL, and the proportion of TMC and TPP is 3：2.

关 键 词：壳聚糖 三甲基壳聚糖 纳米粒 

分 类 号：R943[医药卫生—药剂学]