Measurement and correlation of solubility of meropenem trihydrate in binary(water＋acetone/tetrahydrofuran) solvent mixtures  

作　　者：Lina Zhou Shichao Du Ting Wang Songgu Wu Zhiqiang Guo Zhao Wang Ling Zhou 

机构地区：[1]School of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Tianjin University, Tianjin 300072, China [2]The Co-Innovation Center of Chemistry and Chemical Engineering of Tianjin, Tianjin 300072, China [3]Tianjin Pharmaceuticals Research Institute Co. Ltd, Tianjin 300000, China

出　　处：《Chinese Journal of Chemical Engineering》2017年第10期1461-1466,共6页中国化学工程学报（英文版）

基　　金：Supported by Tianjin Municipal Natural Science Foundation(16JCYBJC19500);China Ministry of Science and Major National Scientific Instrument Development Project(2016YFF0102503)

摘　　要：The solubility of meropenem trihydrate in water+acetone mixtures and water+tetrahydrofuran mixtures were determined from T=(278.15 to 303.15) K by static method under atmospheric pressure.Effects of solvent composition and temperature on solubility of meropenem trihydrate were discussed.To extend the applicability of the solubility data,experimental solubility data in two kinds of binary solvent mixtures were correlated by the Apelblat equation and NIBS/Redlich–Kister model.It was found that the two models could satisfactorily correlate the experimental data and the Apelblat equation could give better correlation results.The solubility of meropenem trihydrate in water＋acetone mixtures and water＋tetrahydrofuran mixtures were determined from T=（278.15 to 303.15） K by static method under atmospheric pressure.Effects of solvent composition and temperature on solubility of meropenem trihydrate were discussed.To extend the applicability of the solubility data,experimental solubility data in two kinds of binary solvent mixtures were correlated by the Apelblat equation and NIBS/Redlich–Kister model.It was found that the two models could satisfactorily correlate the experimental data and the Apelblat equation could give better correlation results.

关 键 词：Solubility Meropenem trihydrate Thermodynamics 

分 类 号：O645.12[理学—物理化学] TQ251.14[理学—化学]