2型糖尿病绝经后女性患者骨代谢标志物与骨密度的关系研究  

Study on the relationship between bone metabolic markers and bone mineral density in postmenopausal women with type 2 diabetes mellitus

作　　者：应蓉[1] 顾涛[1] 周吉[1] 庄丽英[1] 周营[1] 戈少红 蔡杏娟 

机构地区：[1]上海市黄浦区中心医院内分泌科,上海200002

出　　处：《临床医学研究与实践》2017年第18期12-13,16,共3页Clinical Research and Practice

基　　金：上海市黄浦区科学技术委员会科研项目(No.HKW201510)

摘　　要：目的探讨2型糖尿病绝经后女性患者的骨代谢标志物与骨密度的关系。方法收集159例2型糖尿病绝经后女性患者的临床资料,根据骨密度将其分为骨量正常组(n=48)、骨量减少组(n=58)、骨质疏松组(n=53)。比较三组患者的血钙、血磷、25-OH-D3、PTH、BGP、PICP、尿NTX等指标。结果骨质疏松组患者的BGP、PICP、尿NTX水平高于正常组和骨量减少组,差异有统计学意义(P<0.05)。三组患者的血钙、血磷、25-OH-D3、PTH水平比较,差异无统计学意义(P>0.05)。Pearson相关性分析显示,2型糖尿病绝经后女性患者的骨密度与BGP、PICP、尿NTX水平呈明显负相关。结论 BGP、PICP、尿NTX水平能反映2型糖尿病绝经后女性患者骨密度,检测血BGP、PICP、尿NTX及骨密度有助于预测2型糖尿病绝经后女性患者骨质疏松的风险。Objective To invesligale the relationship between bone metabolic markers and bone mineral density in post-menopausal women with type 2 diabetes mellitus. Methods Clinical data of 159 cases of postmenopausal women with type 2 diabetes mellilus were collected. All lhe palienls were dividedinlo normal bone mass group （n=48）, decreased bone mass group （n=58） and osleoprosis group （n=53） according lo lhe bone mineral density. The levels of serum calcium, phosphorus, 25 -OH-D3, PTH, BGP, PICP and urinary NTX were compared between lhe three groups. Results The levels of BGP, PICP and urinary NTX in lhe osleoprosis group were significantly higher than those in lhe normal group and decreased bone mass group （P〈0.05）. There were no significant differences in serum calcium, phosphorus, 2 5 -OH-D3 and PTH levels be-tween lhe three groups （P〉0.05）. Pearson correlation analysis showed lhal bone mineral density in postmenopausal women with type 2 diabetes was negatively correlated with BGP, PICP and urinary NTX levels. Conclusion Levels of BGP, PICP and urinary NTX can reflect bone mineral density in postmenopausal women with type 2 diabetes mellilus. Detection of BGP, PICP and urinary NTX and bone mineral density can help predict lhe risk of osteoporosis in postmenopausal women with type 2 diabetes mellilus.

关 键 词：2型糖尿病 绝经后女性 骨密度 骨代谢标志物 

分 类 号：R580[医药卫生—内分泌] R587.1[医药卫生—内科学]