儿童肿瘤患者口服靶向药后胃肠不良反应发生率的Meta分析  

Gastrointestinal adverse reaction rate after oral targeted agents in pediatric cancer patients:a meta-analysis

作　　者：孟详喻 曾梓航 陈佳峰 刘尚勤[1] 何莉[1] 

机构地区：[1]武汉大学中南医院,武汉430071

出　　处：《内科急危重症杂志》2017年第5期390-392,409,共4页Journal of Critical Care In Internal Medicine

基　　金：国家自然科学基金(No:81272627)

摘　　要：目的:对儿童肿瘤患者口服靶向药后胃肠不良反应事件发生率进行meta分析。方法:在Pubmed文献数据库中检索相关文献。根据纳入与排除标准筛选纳入研究并进行质量评价。提取基本情况与胃肠不良反应事件率数据,logit转换后进行meta分析。结果:本研究共纳入13项临床试验。除厌食外,其他结局meta分析有显著异质性。腹泻合并发生率及其95%CI为0.20[0.13~0.28],恶心为0.19[0.14~0.26],呕吐为0.17[0.12~0.24],厌食为0.06[0.04~0.11]。结论:儿童肿瘤患者在接受口服靶向抗肿瘤药物治疗后可能出现胃肠不良反应,临床应用时应充分认识并监测。Objective：To perform a meta-analysis on the rate of gastrointestinal adverse reactions after oral targeted agents in pediatric cancer patients.Methods：The Pubmed database was searched for relevant articles.Eligible studies were selected according to predefined inclusion and exclusion criteria,and the quality of study was evaluated.Basic information and gastrointesitnal adverse event rate data were extracted,and meta-analysis was conducted after logit transformation.Results：A total of 13 trials were included.Significant heterogeneity was found for diarrhea,nausea and vomiting.Pooled event rate and its95% confidence interval was 0.20[0.13-0.28],0.19[0.14-0.26],0.17[0.12-0.24],and 0.06[0.04-0.11],respectively for diarrhea,nausea,vomiting,and anorexia.Conclusions：Gastrointestinal adverse events may happen in pediatric cancer patients after oral targeted therapy,and close monitoring and preparation is important.

关 键 词：儿童 肿瘤 口服靶向药物 胃肠不良反应 META分析 

分 类 号：R979.1[医药卫生—药品]