fas基因启动子区多态性与乳腺癌发病风险关系的Meta分析  

Relationship between fas gene promoter polymorphisms and breast cancer onset risk:a meta analysis

作　　者：张晓燕[1] 杨波[1] 朱妙仪[1] 刘彦慧[1] 

机构地区：[1]广东省东莞市妇幼保健院产前诊断中心,523112

出　　处：《检验医学与临床》2017年第22期3323-3327,共5页Laboratory Medicine and Clinic

基　　金：广东省东莞市社会科技发展项目(201550725000094;东科[2015]202号)

摘　　要：目的系统评价fas基因启动子区-1377G/A和-670A/G多态性与乳腺癌发病风险的相关性。方法检索电子数据库PubMed、Embase、Web of Science、CNKI、Wanfang Data和CBM,截止日期为2017年2月10日,按纳入与排除标准筛选文献。采用Stata13.0软件进行Meta分析,评估发表偏倚并进行敏感度分析。结果共纳入11篇研究,合并结果显示:未发现fas基因启动子区-1377G/A和-670A/G多态性与乳腺癌发病风险有关联;Egger′s线性回归分析显示不存在发表偏倚(P>0.05);逐个剔除研究后,发现Meta分析结果受单个研究的影响较小。结论 fas基因启动子区-1377G/A和-670A/G多态性可能与乳腺癌的发病风险无关。ObjectiveTo systematically evaluate the relationship between fas gene promoter region（ 1377 G/A and 670 A/G）polymorphisms and breast cancer onset risk.MethodsThe electronic databases of PubMed,Embase,Web of Science,CNKI,Wanfang Data and CBM were retrieved until to expiration date February 10,2017.The literatures were screened according to the inclusion and exclusion standard.The meta analysis was performed by using the Stata 13.0 software.The publication bias was evaluated and sensitivity analysis was also performed.ResultsA total of 11 studies were included.The combined results showed that there was no association between fas gene promoter region（ 1377 G/A and 670 A/G）polymorphisms and breast cancer onset risk.The Egger＇s linear regression analysis revealed that no publication bias existed（P〉0.05）.After getting rid of studies one by one,it was found that meta analysis results received little influence by single study.Conclusionfas gene promoter region（ 1377 G/A and 670 A/G）polymorphisms may have no association with breast cancer onset risk.

关 键 词：乳腺癌 FAS基因 多态性 META分析 对照研究 

分 类 号：R593.2[医药卫生—内科学]