曲美他嗪联合美托洛尔对心脏起搏患者房颤情况及其对AST、LDH及CK-MB的影响  

Influence of trimetazidine combined with metoprolol on atrial fibrillation,AST,LDH and CK-MB in patients with cardiac pacemaker

作　　者：吴中杰[1] 邵江[1] 张建明[1] 石伟[1] 尹丽[1] 

机构地区：[1]重庆三峡中心医院心血管内科,404000

出　　处：《检验医学与临床》2017年第22期3361-3363,共3页Laboratory Medicine and Clinic

摘　　要：目的研究曲美他嗪联合美托洛尔对心脏起搏患者房颤情况及其对天门冬氨酸氨基转移酶(AST)、乳酸脱氧酶(LDH)、肌酸激酶同工酶(CK-MB)的影响。方法选取2014年4月至2016年4月该院植入心脏双腔起搏器的病态窦房结综合征患者80例。采用随机数字表法分为观察组及对照组各40例。对照组患者在起搏器植入后3个月予以美托洛尔治疗,观察组患者则在对照组的基础上加用曲美他嗪治疗。分别比较2组患者房颤发生率、模式转换次数、房颤负荷,血清AST、LDH、CK-MB水平,左心室射血分数(LVEF)、左心室收缩末径(LVESD)、左心室舒张末径(LVEDD)水平及生命质量。结果观察组房颤发生率、模式转换次数、房颤负荷均明显低于对照组,差异有统计学意义(P<0.05)。治疗后观察组AST、LDH、CK-MB水平分别为(38.2±7.2)U/L、(224.3±58.9)U/L、(21.9±4.4)U/L,均明显低于对照组的(46.7±8.4)U/L、(283.2±62.7)U/L、(30.2±7.3)U/L,差异均有统计学意义(P<0.05)。治疗后观察组患者LVEF水平明显高于对照组,而LVESD、LVEDD水平均明显低于对照组,差异均有统计学意义(P<0.05)。观察组生理功能、生理职能、躯体疼痛、社会功能、精力、情感职能、精神健康、总体健康评分均明显高于对照组,差异有统计学意义(P<0.05)。结论曲美他嗪联合美托洛尔能有效降低心脏起搏患者的房颤发生率,改善AST、LDH、CK-MB水平及心功能,有利于提高患者生命质量。ObjectiveTo study the influence of trimetazidine combined with metoprolol on atrial fibrillation,AST,LDH and CK MB in the patients with cardiac pacemaker.MethodsEighty patients with sick sinus syndrome implanted by dual chamber pacemaker in this hospital from April 2014 to April 2016 were selected and divided into the observation group and control group according to the random number table method,40 cases in each group.The control group was given metoprolol treatment after 3 months of pacemaker implantation,while on this basis the observation group was added with trimetazidine.The atrial fibrillation occurrence rate,mode conversion times,AF load,serum AST,LDH,CK MB levels,LVEF,LVESD and LVEDD levels and quality of life were compared between the two groups.ResultsThe atrial fibrillation incidence rate,mode conversion times and AF load in the observation group were significantly lower than those in the control group,the differences were statistically significant（P〈0.05）.The AST,LDH and CK MB levels after treatment in the observation group were（38.2±7.2）U/L,（224.3±58.9）U/L and（21.9±4.4）U/L respectively,which were significantly lower than（46.7±8.4）U/L,（283.2±62.7）U/L and（30.2±7.3）U/L in the control group,the differences were statistically significant（P〈0.05）.After treatment,the LVEF level in the observation group was significantly higher than that in the control group,while the LVESD and LVEDD levels were significantly lower than those in the control group,the differences were statistically significant（P〈0.05）.The scores of physiological function,physiological function,body pain,social function,energy,role emotional,mental health and general health in the observation group were significantly higher than those in the control group,the differences were statistically significant（P〈0.05）.ConclusionTrimetazidine combined with metoprolol can effectively reduce the incidence rate of atrial fibrillation in the patients with cardiac pacemaker,improves the AST,LDH and CK MB

关 键 词：心脏起搏 心房颤动 曲美他嗪 美托洛尔 心肌酶 

分 类 号：R542.22[医药卫生—心血管疾病]