呼出气一氧化氮水平与支气管哮喘患儿病情及炎症因子的关系研究  

Research on the Relationship Between Fractional Exhaled Nitric Oxide Levels and Children with Bronchial Asthma and Inflammatory Factors

作　　者：周武斌[1] 李开为[1] 利莉[1] 吴颖 王冠[1] 

机构地区：[1]黄石市中心医院/湖北理工学院附属医院儿科,湖北黄石435000

出　　处：《现代生物医学进展》2017年第30期5896-5899,共4页Progress in Modern Biomedicine

摘　　要：目的:研究呼出气一氧化氮(FeNO)水平与支气管哮喘患儿病情及炎症因子的关系。方法:选择从2014年9月到2016年9月在我院接受治疗的支气管哮喘患儿115例作为观察组,另选同期来我院体检的健康儿童115例作为对照组,对比两组FeNO及炎症因子的水平,比较观察组不同病情患儿FeNO及炎症因子水平,分析患儿FeNO与病情及炎症因子的相关性。结果:观察组C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)以及FeNO水平分别为(5.06±1.29)mg/L、(4.32±1.33)pg/mL、(2.37±0.21)pg/mL、(50.82±18.28)ppb,均分别显著高于对照组的(1.33±0.46)mg/L、(1.52±0.48)pg/mL、(0.28±0.11)pg/mL、(18.23±2.46)ppb(均P<0.05)。观察组急性发作期患儿CRP、IL-6、TNF-α以及FeNO水平分别为(5.12±1.30)mg/L、(4.49±1.06)pg/mL、(2.48±0.19)pg/mL、(51.27±10.63)ppb,均分别显著高于缓解期的(2.97±0.82)mg/L、(2.39±0.62)pg/mL、(1.52±0.20)pg/mL、(32.41±5.52)ppb(均P<0.05)。根据Spearman法相关性分析可知,患儿FeNO与病情及IL-6、CRP、TNF-α均呈正相关(r=0.736、0.684、0.713、0.594;均P<0.05)。结论:支气管哮喘患儿的FeNO与炎症因子水平呈高表达,FeNO与病情及炎症因子之间密切相关,临床上可将其纳入监测指标,有助于辅助治疗支气管哮喘患儿。Objective： To study the relationship between fractional exhaled nitric oxide levels and children with bronchial asthma and inflammatory factors. Methods： 115 children with bronchial asthma who were treated in our hospital from September 2014 to September 2016 were selected as the observation group. Over the same period, 115 cases of healthy children volunteers in the hospital were selected as control group, the levels of FeNO and inflammatory factors were compared between the two groups. The levels of FeNO and inflammatory factors of children with different stages in the observation group were observed. The correlation between FeNO and the disease and inflammatory factors were analyzed. Results： The levels of C reactive protein （CRP）, interleukin -6 （IL-6）, tumor necrosis factor-α （TNF-α and FeNO in observation group were （5.06± 1.29）mg/L, （4.32±1.33）pg/mL, （2.37± 0.21）pg/mL, （50.82± 18.28）ppb, which were significantly higher than （1.33 ± 0.46）mg/L, （1.52± 0.48）pg/mL, （0.28± 0.11）pg/mL and （18.23 ±2.46）ppb in the control group （P〈0.05）. The levels ofCRP, IL-6, TNF-α and FeNO of observation group of children with acute attack stage were （5.12± 1.30） mg/L,（4.49± 1.06）pg/mL, （2.48± 0.19）pg/mL, （51.27± 10.63）ppb, which were significantly higher than （2.97± 0.82）mg/L, （2.39±0.62） pg/mL, （1.52±0.20）pg/mL, （32.41± 5.52）ppb in the remission stage （P〈0.05）. According to the correlation analysis of Spearman method, the results showed that the FeNO of patients with disease and CRP and IL-6, TNF-α were positively correlated （r=0.736, 0.684, 0.713, 0.594, all P〈0.05）. Conclusion： The expression of FeNO and inflammatory factors in children with bronchial asthma is high, and FeNO is closely related to the disease and inflammatory factors, it can be incorporated into the monitoring indicators, which is helpful for the treatment of children with bronchial asthma.

关 键 词：呼出气 一氧化氮 支气管哮喘 病情 炎症因子 关系 

分 类 号：R562.25[医药卫生—呼吸系统]