超氧化物歧化酶联合腺苷脱氨酶诊断结核性胸腔积液  

Diagnostic Value of Superoxide Dismutase Combined with Adenosine Deaminase in Tuberculous Pleurisy Effusion

作　　者：孙珍贵[1] 臧蕾蕾 陈兴无[1] 

机构地区：[1]皖南医学院弋矶山医院呼吸内科,安徽芜湖241001

出　　处：《沈阳医学院学报》2017年第6期487-489,492,共4页Journal of Shenyang Medical College

摘　　要：目的:观察血清及胸腔积液中超氧化物歧化酶(SOD)和腺苷脱氨酶(ADA)的水平变化,探讨SOD联合ADA对结核性胸腔积液(TPE)的诊断价值。方法:通过检测51例TPE和46例恶性胸腔积液(MPE)患者胸腔积液及血清ADA、SOD水平,观察两者单独或联合检测诊断TPE的敏感性及特异性。结果:TPE组胸腔积液ADA值、胸腔积液ADA/血清ADA明显高于MPE组,差异有统计学意义(P<0.05);2组患者血清ADA值比较,差异无统计学意义(P>0.05)。胸腔积液SOD截点值取<78 U/ml,诊断TPE的灵敏度为88%,特异度为79%;胸腔积液ADA/血清ADA截点值取>1,其灵敏度为88%,特异度为84%;两者联合检测TPE,胸腔积液SOD<78 U/ml、胸腔积液ADA/血清ADA>1时其灵敏度为91%,特异度为89%。结论:SOD联合ADA检测在TPE中可能有较高的临床诊断价值。Objective:To investigate the diagnostic value of superoxide dismutase(SOD)combined with adenosine deaminase(ADA)in tuberculous pleurisy effusion(TPE). Methods:A total of 51 cases of patients with TPE and 46 cases of patients with malignant pleural effusion(MPE)were selected and the levels of SOD and ADA in serum and pleural effusion were detected to investigate the diagnostic sensitivity and specificity. Results:The level of ADA in pleural effusion and the ratio of pleural effusion ADA to serum ADA in TPE group were significantly higher than those in MPE group(P<0.05),while serum ADA levels had no significant difference between the two groups(P>0.05). The sensitivity and specificity of SOD in pleural effusion in the diagnosis of TPE was 88% and 79% respectively(cut-off value <78 U/ml). The sensitivity and specificity in the diagnosis of TPE was 88% and84% respectively when the cut-off value of pleural effusion ADA/serum ADA >1. However,the sensitivity and specificity of SOD combined with ADA in the diagnosis of TPE was 91% and 89% respectively. Conclusion:SOD combined with ADA may have a high clinical value in the differential diagnosis of TPE.

关 键 词：结核性胸膜炎 超氧化物歧化酶 腺苷脱氨酶 诊断 

分 类 号：R519.1[医药卫生—内科学]