新生儿手足口病8例临床分析  

Clinical analysis of 8 cases of neonatal hand-foot-mouth disease

作　　者：周高枫[1] 王红梅[1] 田树凤[1] 邓继岿[1] 

机构地区：[1]深圳市儿童医院感染科,广东深圳518038

出　　处：《临床儿科杂志》2017年第11期857-859,共3页Journal of Clinical Pediatrics

摘　　要：目的分析新生儿手足口病的临床特点、治疗及预后。方法回顾分析2014年7月—2016年5月间收治的8例新生儿手足口病患儿的临床资料,所有患儿均采用实时荧光定量PCR法进行咽拭子肠道病毒通用型核酸、EV 71和CA 16核酸检测。结果 8例新生儿手足口病,男6例、女2例,日龄7~26天;7例有接触史;临床表现为出疹(8例)、发热(6例)、烦躁(4例)、呕吐(1例),无惊厥、抽搐。RT-PCR检测肠道病毒显示均为非EV71、非CA16的其他肠道病毒感染。5例合并肺部感染,给予抗生素治疗。8例均预后良好。结论新生儿手足口病多有接触史,临床表现无特异性,以非EV71、非CA16肠道病毒为主,易合并肺部感染。Objective To study the clinical features, treatment and prognosis of neonatal hand-foot-mouth disease. Methods Neonatal hand-foot-mouth disease patients admitted from July 2014 to May 2016 were retrospectively studied. EV71, CA16 and universal enterovirus were detected from newborn swabs by RT-PCR. Results A total of 8 neonatal patients with hand-foot-mouth diseases, 6 boys and 2 girls were diagnosed at an age ranged from 7-26 days. Of them, 7 patients had exposure history. Clinical manifestations including rash （8 cases）, fever （6 cases）, irritability （4 cases） and vomiting （1 case）, nobody suffered convulsions. The results of RT-PCR showed pathogen enterovirus not- EV71 and not-CA16. There were 5 cases of pulmonary infection treated with antibiotic therapy. All of the 8 cases had a good prognosis. Conclusions Most of the hand- foot-mouth diseases had exposure history without specific clinical manifestations. They had not- EV71 and not-CA16 intestinal virus infection, some patients had pulmonary infection. Therefore, neonatal hand-foot-mouth diseases need more clinical attention.

关 键 词：手足口病 肠道病毒 新生儿 

分 类 号：R725.1[医药卫生—儿科]