围产期氟暴露对仔鼠焦虑行为的影响  

Effect of Fluoride Exposure During Perinatal Stage on Anxiety Behaviors of Mouse Pups

作　　者：曹国弟[1,2] 张玉良[2] 张孝清[1] 孙子龙[2] 

机构地区：[1]朔州职业技术学院,山西朔州036002 [2]山西农业大学动物科技学院,山西太谷030801

出　　处：《动物医学进展》2017年第11期91-93,共3页Progress In Veterinary Medicine

基　　金：国家自然科学基金项目(31201965)

摘　　要：氟对机体的神经毒性渐渐引起了人们的重视,为研究氟中毒对小鼠焦虑行为的影响,采用高架O迷宫检测断奶仔鼠的行为学,用Smart V 3.0跟踪系统采集数据,分析仔鼠行为学变化。母鼠在围产期的饮用水中分别添加0、25、50、100mg/L氟化钠,仔鼠出生21日龄开始检测其行为学变化。结果与对照组相比,加氟组进入开放区的次数、时间、跑动的路程均减少,说明围产期氟暴露会增加后代焦虑症状的发生。The neurotoxicity of fluorine has gradually aroused people＇s attention.In order to study the effects of fluorosis on anxious behavior in mice, this experiment analyzed the behavior changes in weaned mouse pups adopting the elevated O maze test and using Smart V 3.0 tracking system to collect data.Female mice of perinatal stage were added with 0,25,50,and 100 mg/L sodium fluoride in their drinking water.The behavioral change test was conducted on postnatal day 21 of the mouse offspring. The results showed that compared to the control group, the numbers and time entering open area and running distance were reduced in the mice of add fluoride group,indicating that perinatal fluorine exposure may increase the anxiety incidence of the offspring.

关 键 词：氟中毒 焦虑 小鼠 O迷宫 

分 类 号：S859.8[农业科学—临床兽医学]