慢性胃炎动物模型复制进展  

Research Progress in Animal Model Replication of Chronic Gastritis

作　　者：辛竞[1] 王新茗 张仲林[2] 唐旭[3] 袁明勇[1] 

机构地区：[1]成都医学院第一附属医院药剂科,成都610500 [2]成都医学院药学院,成都610500 [3]成都医学院校医院,成都610500

出　　处：《中国药师》2017年第11期2053-2056,共4页China Pharmacist

基　　金：四川省科技厅项目(编号:2014JY0019);四川省教育厅项目(编号:14ZA0227)

摘　　要：慢性胃炎(CG)是消化系统的一种常见病,动物模型的复制在CG的发病机制、治疗机理及相关新药研发方面尤为重要,但目前尚无CG自发性动物模型。本文查阅了近年来的研究文献,对动物模型的各种复制方法进行了系统梳理并做了全新分类归纳,进一步对每类方法的成模机理、注意事项及成模率进行了简洁、科学和客观的评价,以期开拓研究者的研究思路和提供研究参考。Chronic gastritis （CG） is a common disease of digestive system. It is of the utmost importance to reply the animal mod- el of CG in the researches on pathogenesis, treatment mechanism and drugs development. It＇ s necessary to review the general situation about the replication of CG animal model since there is no spontaneous animal model of CG. The research literatures related to the replication of CG animal model in recent years were reviewed, all kinds of methods on the animal model replication were reorganized systemically, and a new classification was established. Furthermore, the model mechanism, precautions and success rate of each classification method were evaluated concisely, scientifically and objectively in order to exploit the research ideas of researchers and provide reference for further studies.

关 键 词：慢性胃炎 动物模型 复制研究 

分 类 号：R965.2[医药卫生—药理学]