两种卡铂注射液与输液的配伍稳定性考察  被引量:7

Compatibility stability of two carboplatin injections with 2 commonly used solvents

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作  者:穆薇[1] 闵婕[2] 李诗草[1] 闫涛[1] 刘琳娜[1] 

机构地区:[1]第四军医大学唐都医院药剂科,陕西西安710038 [2]第四军医大学医院肿瘤科,陕西西安710038

出  处:《中国医院药学杂志》2017年第20期2093-2096,共4页Chinese Journal of Hospital Pharmacy

基  金:第四军医大学第二附属医院2015年院创新项目(编号:2015LCYJ016)

摘  要:目的:考察两种卡铂注射液与输液的配伍稳定性。方法:将两种卡铂注射液分别使用0.9%氯化钠、5%葡萄糖溶液稀释,分别在25℃和42℃下于0,2,4,6,8,12,24 h时观察配伍液的外观变化,测定其pH值,采用高效液相色谱法测定配伍液中卡铂的相对百分含量。结果:在上述条件下,配伍液在24 h内外观和pH值均无明显变化;齐鲁卡铂各时间点、各配伍液中卡铂的相对百分含量为94.55%~100.64%,RSD<2%;施贵宝卡铂各时间点、各配伍液中卡铂的相对百分含量为91.55%~100.37%,RSD<3%。结论:两种卡铂注射液与0.9%氯化钠注射液、5%葡萄糖注射液配伍后,在25℃和42℃条件下,24 h内稳定,在葡萄糖中稳定性更好。OBJECTIVE To investigate the compatibility stability of two carboplatin injections with 2 commonly used solvents.METHODS After two carboplatin injections were respectively added into 0.9% sodium chloride injection and 5% glucose solution,the appearances of the mixture were respectively observed under 25 ℃ and 42 ℃ at 0,2,4,6,8,12,24 h.The pH value was measured and high performance liquid chromatography(HPLC)was used to determine the contents of carboplatin.RESULTS Under this condition,the appearance and pH value had no obvious change within 24 h.The contents of Qilu carboplatin were 94.55% ~100.64%,RSD2%.The contents of Bristol-Myers Squibb carboplatin were 91.55% ~100.37%,RSD3%.CONCLUSION After mixed with0.9%sodium chloride injection and 5% glucose injection,two carboplatin injections are stable within 24 h at 25 ℃ and 42 ℃.Glucose solution shows better stability.

关 键 词:卡铂 高效液相色谱法 含量 配伍 稳定性 

分 类 号:R927[医药卫生—药学]

 

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