肥厚型心肌病患者右室功能变化的超声心动图研究  

Echocardiographic Analysis of Right Ventricular Function in Patients with Hypertrophic Cardiomyopathy

作　　者：蒲利红[1] 李嵘娟[1] 谢瑾捷 王月丽[1] 张涵[1] 马宁[1] 杨娅[1] 

机构地区：[1]首都医科大学附属北京安贞医院超声心动图一部,北京市100029

出　　处：《中国超声医学杂志》2017年第10期896-899,共4页Chinese Journal of Ultrasound in Medicine

基　　金：国家自然科学基金(No.81171351)

摘　　要：目的探讨肥厚型心肌病(HCM)患者右室功能变化及其与左室功能及室壁厚度的关系。方法纳入HCM单纯左室肥厚组(HCM组)23例、HCM合并右室肥厚组(HCM+RVH组)16例及健康受试者30例,分析比较三组常规超声心动图参数和应变参数,并分析右室纵向应变与左室纵向应变、室间隔及右室壁厚度的相关性。结果 HCM患者左室整体长轴应变(LV GLS)、右室整体长轴应变(RV GLS)及节段应变绝对值均明显减小,HCM+RVH组较为显著(P<0.05);HCM患者右室收缩期应变率(GRSs)绝对值、舒张早期应变率(GRSe)较对照组减小(P<0.005);HCM+RVH组舒张晚期应变率(GRSa)较对照组及HCM组减小(P<0.05);RV GLS绝对值与LV GLS绝对值呈正相关、与室间隔厚度及右室壁厚度均呈负相关(相关系数分别为0.575、-0.551、-0.364,P<0.05)。结论 HCM患者右室收缩及舒张功能均有不同程度的减低,且合并右室肥厚的患者右室功能减低更明显;HCM患者右室功能与左室功能呈正相关,与室间隔厚度、右室壁厚度呈负相关。Objective To evaluate right ventricular function in HCM patients, and evaluate the correlation be- tween right ventricular function and left ventricular function and the ventricular wall thickness. Methods 45 HCM pa- tients without right ventricular hypertrophy（HCM）,22 patients with right ventricular hypertrophy（HCM＋RVH）and 30 healthy people were enrolled. Compared all parameters and analyze the correlations. Results Right and left ven- tricular strain in HCM patients all decreased, and HCM＋RVH group more significantly（P〈0.05） ;Right ventricular systolic strain rate（GRSs）and early diastolic strain rate（GRSe）in HCM patients decreased（P〈0. 005）;Late diastolic strain rate（GRSa）in HCM＋ RVH group were smaller than other two groups （P〈 0. 05） ; Absolute of RV GLS was correlated with LV GLS,interventricular septal thickness and right ventricular wall thickness, and the correlation coffi- cient was 0. 575,-0. 551,-0. 364 respectively（P〈0.05）. Conclusions Right ventricular function decrease in HCM patients,and patients with right ventricular hypertrophy more significantly;There is positive correlation between right and left ventricular function,negative correlation between right ventricular function and the ventricular wall thickness.

关 键 词：肥厚型心肌病 右心室功能 超声心动图 二维应变 

分 类 号：R540.45[医药卫生—心血管疾病] R542.2[医药卫生—内科学]