我院35例低分子右旋糖酐氨基酸注射液致ADR分析  

Analysis of 35 Cases of ADR Induced by Low-molecular Dextran and Amino Acid Injection in Our Hospital

作　　者：饶芸[1] 骆群[1] 徐萍[1] 王智[1] 

机构地区：[1]第三军医大学第一附属医院普通外科/微创胃肠外科中心,重庆400038

出　　处：《中国药房》2017年第32期4510-4513,共4页China Pharmacy

摘　　要：目的:了解低分子右旋糖酐氨基酸注射液致不良反应(ADR)发生的特点和规律,为临床安全用药提供参考。方法:收集我院2010年1月-2017年1月上报的35例低分子右旋糖酐氨基酸注射液致ADR报告,对患者性别、年龄、ADR报告类型和发生时间、原患疾病及既往药物过敏史、ADR累及器官/系统及临床表现、转归等进行回顾性统计分析。结果:35例低分子右旋糖酐氨基酸注射液致ADR报告中,男性18例(51.43%),女性17例(48.57%);患者年龄最小11岁,最大80岁,平均年龄48.2岁。严重的ADR 4例(11.43%),一般的ADR 31例(88.57%);ADR在用药后10 min^1 h发生率高(71.43%);ADR所涉及的原患疾病以骨折(14例,40.00%)和膝关节炎(8例,22.86%)为主;ADR主要累及消化系统(34.29%)、循环系统(22.86%)和皮肤及其附件(20.00%)等;所有患者在停药及对症处理后均好转或治愈。结论:低分子右旋糖酐氨基酸注射液致ADR的发生率不高,但可致严重的ADR,护理人员可对其加强监护,以减少并发症的发生,避免医患矛盾。OBJECTIVE： To investigate the characteristics and the regularity of ADR induced by Low-molecular dextran and amino acid injection, and to provide reference for safe use of drugs in clinic. METHODS： Among 35 cases of ADR induced by Low-molecular dextran and amino acid injection were collected from our hospital during Jan. 2010-Jan. 2017. Those ADR cases were analyzed statistically in respects of patients＇gender and age, type and occurrence time of ADR cases, primary disease, aller- gic history, organs/systems involved in ADR, clinical manifestations, outcomes, etc. RESULTS： Among 35 cases of ADR induced by Low-molecular dextran and amino acid injection, there were 18 male （51.43%） and 17 female （48.57%） . The youngest patient was 11 years old, the oldest patient was 80 years old, the average age was 48.2 years. There were 4 cases of severe ADR （11.43%） and 31 cases of common ADR （88.57%）. ADR mostly occurred 10 min-1 h after medication （71.43%）. Bone fractures （14 cases, 40.00% ） and knee inflammation （8 cases, 22.86% ） were main original disease involved in ADR. Main organs or sys- tems involved in ADR were digestive system（34.29% ）, circulatory system（22.86% ）, skin and its appendants （20.00%）, etc. All cases were recovered or cured after drug withdrawal and systematic treatment. CONCLUSIONS： Low-molecular dextran and amino acid injection induce low incidence of ADR but can induce severe ADR. The nursing staff should strengthen ADR monitoring to re- duce the occurrence of complications and avoid medical staff-patient dispute.

关 键 词：低分子右旋糖酐氨基酸 不良反应 合理用药 护理 

分 类 号：R969.3[医药卫生—药理学]