316例输卵管性不孕患者生殖道Ct、Uu及Mh的检测及耐药性分析  

Detection and drug resistance of Ct,Uu and Mh in genital tracts of 316 patients with tubal infertility

作　　者：邹亦庐[1] 江丽[2] 吴建波[1] 陈丽红[1] 胡继芬[1] 

机构地区：[1]福建医科大学附属第一医院妇产科,福建福州350005 [2]福建医科大学附属第一医院检验科,福建福州350005

出　　处：《中国微生态学杂志》2017年第9期1066-1068,共3页Chinese Journal of Microecology

摘　　要：目的通过对316例输卵管性不孕患者生殖道沙眼衣原体、解脲支原体、人型支原体感染以及耐药情况进行检测分析,研究其与不孕症的关系,并探讨用药合理性。方法收集316例2013年2月至2016年9月至我院进行诊治的输卵管性不孕患者作为研究组,并选取同期297例来进行检查的健康人作为对照组。对两组人员生殖道分泌物进行沙眼衣原体(Chlamydia trachomatis,Ct)、解脲支原体(Ureaplasma urealyticum,Uu)、人型支原体(Mycoplasma hominis,Mh)检测,并进行药敏试验。结果研究组患者Ct、Uu、Mh、Ct+Uu、Uu+Mh感染率以及总感染率均明显高于对照组,差异均具有统计学意义(Ps<0.05)。Uu对原始霉素、四环素、强力霉素、交沙霉素、阿奇霉素、克拉霉素、红霉素敏感性较高(90%以上),对氧氟沙星、环丙沙星耐药性较高。Mh对原始霉素、四环素、强力霉素、交沙霉素敏感性较高(90%以上),对氧氟沙星、环丙沙星、阿奇霉素、克拉霉素耐药性较高。Uu+Mh对原始霉素、四环素、交沙霉素敏感性较高(90%以上),对阿奇霉素、氧氟沙星、环丙沙星耐药性较高。结论对输卵管性不孕患者,应进行生殖道分泌物Ct、Uu、Mh的检测,判断是否发生感染或混合感染,并根据药敏结果选择合适的抗生素进行治疗,以提高治疗效果。Objective To detect the pathogens in tubal infertility patients with genital Chlamydia trachomatis（Ct）,Ureaplasma urealyticum（Uu）and Mycoplasma hominis（Mh）as well as their drug resistance,analyze their relationship with infertility,and discuss rational use of drugs.Methods 316 patients with tubal infertility from February 2013 to September 2016 in our hospital were selected as the observation group,with 297 healthy individuals as the control group.The genital tract secretions of the subjects were detected for Ct,Uu and Mh,and drug resistance test was conducted.Results The infection rates of Ct,Uu,Mh,Ct＋Uu and Uu＋Mh and total infection rate in the observation group were significantly higher than those in the control group（Ps〈0.05）.Uu showed high sensitivities to pristinamycin,tetracycline,doxycycline,josamycin,azithromycin,clarithromycin and erythromycin（more than 90%）,and high resistances to ofloxacin and ciprofloxacin.Mh showed high sensitivities to pristinamycin,tetracycline,doxycycline and josamycin（more than 90%）,and high resistances to ofloxacin,ciprofloxacin,azithromycin and clarithromycin.Uu＋Mh showed high sensitivities to pristinamycin,tetracycline and josamycin（more than 90%）,and high resistances to azithromycin,ofloxacin and ciprofloxacin.Conclusion The detection of Ct,Uu and Mh in genital tract secretions should be performed for patients with tubal infertility to determine whether it is single infection or mixed infection,and antibiotic drugs should be used according to the result of sensitivity test to improve treatment effect.

关 键 词：输卵管性不孕 沙眼衣原体 解脲支原体 人型支原体 耐药性 

分 类 号：R711[医药卫生—妇产科学]