连续性高容量血液滤过对多器官功能障碍综合征患者靶器官功能、C反应蛋白、肿瘤坏死因子-α与内皮损伤因子水平的影响  

Effect of continuous high-volume hemofiltration on target organs function,CRP,TNF-α and vascular endothelial damage factors levels in patients with multiple organ dysfunction syndrome

作　　者：贾顺莲 王玉英 高新英 张彩虹 马志宏 金磊 黄振兴 刘小勇 JIA Shunlian;WANG Yuying;GAO Xinying;ZHANG Cailiong;MA Zhiliong;JIN Lei;HUANG Zhenxing;LIU Xiaoyong(Department of Nephrology,Xining First People＇s Hospital, Xining, Qinghai, 8000)

机构地区：[1]青海省西宁市第一人民医院肾内科,青海西宁810000

出　　处：《实用临床医药杂志》2017年第19期48-51,共4页Journal of Clinical Medicine in Practice

基　　金：青海省西宁市科技局科技开发计划(2014-K-19)

摘　　要：目的观察连续性高容量血液滤过对多器官功能障碍综合征(MODS)患者靶器官功能、血清降钙素原、肿瘤坏死因子-α与内皮损伤因子水平的影响。方法选取54例MODS患者。观察组行疾病基础治疗及间歇性血液透析治疗,实验组在此基础上行连续性高容量血液滤过治疗。比较2组靶器官功能、血清C反应蛋白、肿瘤坏死因子-α与内皮损伤因子水平。结果 2组治疗后的靶器官功能指标均显著低于治疗前(P<0.05),且实验组各指标水平均显著低于观察组(P<0.05);2组治疗后血清降钙素原、肿瘤坏死因子-α水平均显著低于治疗前(P<0.05),且实验组各指标水平均显著低于观察组(P<0.05);2组治疗后的内皮损伤因子水平均显著低于治疗前(P<0.05),且实验组各指标水平均显著低于观察组(P<0.05)。结论连续性高容量血液滤过能够改善多器官功能障碍综合征患者靶器官功能,并缓解血清降钙素原、肿瘤坏死因子-α与内皮损伤因子等指标的水平,有利于保护患者的血管内皮功能,增强临床疗效。ObjectiveTo observe the effect of continuous high volume hemofiltration on target organs function, serum procalcitonin, tumor necrosis factor α and vascular endothelial damage factors levels in patients with multiple organ dysfunction syndrome （MODS）. MethodsA total of 54 patients with multiple organ dysfunction syndrome were selected. Observation group was given basic treatment and intermittent hemodialysis therapy, and experiment group was treated with continuous high volume hemofiltration on the basis of the observation group. The levels of target organs function, serum procalcitonin, tumor necrosis factor α and vascular endothelial damage factors were detected and compared between the two groups. ResultsAfter treatment, the indexes of target organs function in both groups were significantly lower than those before treatment （P〈0.05）, and those levels of the experiment group were significantly lower than those in the observation group （P〈0.05）. The levels of serum procalcitonin and tumor necrosis factor α in the two groups after treatment were significantly lower than those before treatment （P〈0.05）, and those levels of the experiment group were significantly lower than those in the observation group （P〈0.05）. The vascular endothelial damage factors levels of the two groups after treatment were significantly lower than those before treatment （P〈0.05）, and those levels of the experiment group were significantly lower than those in the observation group （P〈0.05）. ConclusionContinuous high volume hemofiltration can improve the target organs functionof patients with multiple organ dysfunction syndrome, reduce the levels of serum procalcitonin, tumor necrosis factor α and vascular endothelial damage factors, which can protect vascular endothelial function and enhance the curative effects.

关 键 词：连续性高容量血液滤过 多器官功能障碍综合征 靶器官功能 血管内皮功能 

分 类 号：R457[医药卫生—治疗学]