504例胃息肉发生相关因素的调查研究  

Factors associated with the occurrence of gastric polyps: a case-control study of 504 pairs

作　　者：何金龙[1] 陈磊[1] 代剑华[1] 张昊翔[1] 冯吉[1] 魏周玲 房殿春[1] 

机构地区：[1]第三军医大学西南医院全军消化病研究所,重庆400038

出　　处：《第三军医大学学报》2017年第22期2226-2231,共6页Journal of Third Military Medical University

摘　　要：目的探讨胃息肉发生的相关因素,为更有针对性胃息肉的预防提供科学依据。方法收集2016年10月至2017年3月就诊于西南医院各科室的504例行胃镜检查并经病理学证实为胃息肉的患者,以同期健康体检和各科室就诊的504例行胃镜检查未发现胃息肉者作为对照,使用统一设计的调查问卷进行相关因素调查。对调查各因素进行单因素分析,将筛选出有统计学意义的因素纳入多因素Logistic回归分析。结果单因素分析结果显示,质子泵抑制剂使用情况、H.pylori感染史、胃息肉家族史、吸烟、饮酒、喝茶、体育锻炼、进食速度、进食水果、心情状况、精神创伤史及工作生活压力可能与胃息肉发生相关。多因素Logistic回归分析结果显示,使用质子泵抑制剂、H.pylori感染史、胃息肉家族史、长期饮酒、进食速度较快、精神创伤史是胃息肉发生的危险因素,体育锻炼(≥1次/周)、进食水果(≥2次/周)为其保护因素。结论胃息肉的发生与多种因素相关,避免长时间使用质子泵抑制剂及长期饮酒、根除H.pylori感染、适当的体育锻炼与进食水果、保持乐观的心态和养成良好的饮食习惯可能会有效降低胃息肉的发生风险。Objective To investigate the factors associated with the occurrence of gastric polyps to provide evidence for devising strategies for its prevention. Methods We retrospectively analyzed 504 cases of gastric polyps diagnosed by gastric endoscopy and subsequent pathological examination from different departments of the Southwest Hospital between October 2016 and March 2017. We also enrolled 504 subjects without gastric polyps during the same period to serve as the control group and paired them with the case group at a 1∶ 1 ratio. The relevant data were collected from all the participants using a self-designed questionnaire.The factors associated with the occurrence of gastric polyps were analyzed with Chi-square test followed by multivariate logistic regression analysis. Results Univariate analysis showed that a history of using protonpump inhibitors（ PPIs）,a history of H. pylori infection,a family history of gastric polyps,smoking,drinking alcohol,drinking tea,physical exercise,eating speed,fruit intake,emotional status,psychological trauma and pressure from work and daily life were all potential factors related to the occurrence of gastric polyps.Multivariate logistic regression analysis identified a history of using PPIs,a history of H. pylori infection,a family history of gastric polyps,long-term alcohol drinking,eating fast and psychological trauma as the risk factors and physical exercise（ not less than once a week） and eating fruits（ not less than twice a week） as the protective factors against the occurrence of gastric polyps. Conclusion Multiple factors contribute to the occurrence of gastric polyps. Avoiding long-term use of PPIs and drinking alcohol,eradication of H. pylori infection,active exercise,sufficient fruit intake,a positive attitude and a good eating habit may effectively reduce the risk of gastric polyps.

关 键 词：胃息肉 相关因素 病例对照 LOGISTIC回归分析 

分 类 号：R195.4[医药卫生—卫生统计学] R573[医药卫生—卫生事业管理]