复方三维右旋泛酸钙糖浆对幼龄大鼠厌食症的治疗作用及机制研究  

Therapeutic effects and mechanisms of compound trivitamin and calcium pantothenate syrup on the young anorexia rats

作　　者：罗西[1,2] 姜溪[3] 只德广[3] 陈芙蓉[3] 王银松[1] 

机构地区：[1]天津医科大学药学院,天津300070 [2]天津市胸科医院药剂科,天津300051 [3]天津药物研究院新药评价有限公司,天津300301

出　　处：《天津医科大学学报》2017年第6期502-505,共4页Journal of Tianjin Medical University

摘　　要：目的:采用幼年大鼠厌食症模型,评价复方三维右旋泛酸钙糖浆的治疗作用,探讨作用机制。方法:构建幼龄大鼠厌食症模型,按剂量分组,给药2周,检测进食量、体质量、血清琥珀酸脱氢酶(SDH)、苹果酸脱氢酶(MDH)、丙酮酸激酶(PK)、生长抑素(SS)、胃泌素(gastrin)及饥饿素(ghrelin),然后进行胃肠运动和胃消化功能试验。结果:灌胃给药后,幼龄厌食症大鼠体质量显著增加,血清MDH与SDH活力升高,gastrin含量增加,ghrelin含量降低,胃液分泌、总酸及游离酸的排出量增加,胃蛋白酶活力升高。结论:复方三维右旋泛酸钙糖浆对幼龄大鼠厌食症有明显的治疗作用,主要机制是增加食欲,促进食物的消化吸收。Objective： To evaluate the therapeutic effects of compound trivitamin and calcium pantothenate syrup and explore its mechanisms by using the young anorexia rat model. Methods： The rat model of anorexia was established using the mixed feed. The anorexia rats were divided into different groups and then continuously administrated at different drug doses for 2 weeks. During the treatment period,the food intakes, body weights, serum levels of SDH, MDH, PK, SS, gastrin, and ghrelin of these rats were detected to evaluate the drug effects. Furthermore, the gastrointestinal movement and stomach digestive function in these rats were also assessed to explore the functional mechanisms of the drug. Results： After intragastric administration, the body weights of these anorexia rats significantly increased, the activities of MDH and SDH in serum were enhanced and the gastrin content increased, but the ghrelin content decreased. In addition, the gastric secretion was promoted, the total acid and free acid excretion increased, and the pepsin activity was elevated. Conclusion：Compound trivitamin and calcium pantothenate syrup has marked therapeutic efficacy on anorexia in young rats, and the increase of appetite, the enhancements of food digestion and absorption may be its main functional mechanisms.

关 键 词：幼龄大鼠 厌食症 消化吸收 胃肠激素 

分 类 号：R9[医药卫生—药学]