膝关节骨性关节炎MR软骨形态及T2值测量与临床相关性  

The correlation between cartilage morphology and T2 value of MR and clinical manifestations in knee osteoarthritis

作　　者：李淑华[1] 张俊祥[1] 刘志军[1] 周莉[1] 宋宏伟[1] 张莉[1] 

机构地区：[1]蚌埠医学院第一附属医院放射科,安徽蚌埠233004

出　　处：《实用放射学杂志》2017年第11期1732-1735,1750,共5页Journal of Practical Radiology

摘　　要：目的 探讨膝关节骨性关节炎（OA）软骨损伤的MRI形态评分及T2值变化与临床表现之间的相关性。方法 收集65例膝关节OA患者及10例健康受试者，接受临床西安大略和麦克马斯特大学骨关节炎指数（WOMAC）评分，行膝关节MRI矢状位3D-WATSc、T2 mapping扫描，根据全器官磁共振评分（WORMS）将患者分为OA1、OA2、OA3组，评价患者软骨WORMS及T2值与临床WOMAC评分的相关性。结果 软骨WORMS与临床表现WOMAC总评分、疼痛、僵硬及活动度各亚领域评分呈正相关，相关系数r分别为0.806、0.690、0.493、0.817，P〈0.05；软骨T2值与临床表现WOMAC总评分、疼痛、僵硬及活动度各亚领域评分呈正相关，相关系数r分别为0.501、0.384、0.357、0.512，P〈0.05。结论 MRI半定量评价指标WORMS及定量评价指标T2值均能在一定程度上反映膝关节OA患者的临床表现。Objective To investigate the correlation between the MRI morphology scoring of cartilage injury, the changes of T2 value and clinical manifestations in knee osteoarthritis （OA）. Methods Ten healthy volunteers and 65 patients with OA were enrolled. The patients were graded according to the Western Ontario and McMaster University Osteoarthritis Index （WOMAC）. Knees of all research participants underwent MRI scanning of sagittal 3D-WATSc and T2 mapping. Patients were further divided into group OA1, group OA2 and group OA3 based on Whole-Organ Magnetic Resonance Imaging Score （WORMS）. The correlation between the WORMS scores, T2 values of the knee cartilages and the clinical WOMAC scores was analyzed.Results The WORMS scores of the cartilages were positively correlated with the total WOMAC scores, pain scores, stiffness scores and activity scores, with the correlation coefficient of 0.806, 0.690, 0.493 and 0.817, respectively （P〈0.05）. The T2 values of the cartilages had a positive corre lation with the total WOMAC scores, pain scores,stiffness scores and activity scores,with the correlation coefficient of 0.501 ,0.384, 0.357 and 0.512, respectively （P〈0.05）.Conclusion WORMS as MRI semi-quantitative evaluation index and T2 values as MRI quantitative evaluation index could reflect clinical manifestations of patients with knee OA to some extent.

关 键 词：膝关节 骨性关节炎 关节软骨 T2图 磁共振成像 

分 类 号：R684.3[医药卫生—骨科学] R445.2[医药卫生—外科学]