超选择动脉KMG化疗栓塞联合RFA治疗中央型肺癌的效果  

Effect of KMG for bronchi arterial chemoembolization combined with RFA for the central lung cancer

作　　者：袁福建 谢树标 朱志诚 

机构地区：[1]赣州市肿瘤医院放射介入科,江西赣州341000

出　　处：《实用放射学杂志》2017年第11期1754-1757,1768,共5页Journal of Practical Radiology

摘　　要：目的 探讨超选择动脉海藻酸钠微球（KMG）化疗栓塞联合射频消融（RFA）治疗中央型肺癌的效果。方法 收集60例经病理证实的鳞状细胞肺癌，确认肿瘤供血动脉后行超选择动脉KMG化疗栓塞，术后1月行经皮穿刺行RFA术，治疗后1个月、3个月、6个月行CT检查观察瘤体变化，抽血检测治疗前、治疗后1个月肿瘤标志物水平，临床症状改善及并发症情况。结果 60例患者中，完全缓解（CR）10例，部分缓解（PR）33例，稳定（SD）11例，进展（PD）6例，治疗后1个月血管内皮生长因子（VEGF）亚型VEGFA、VEGFB，VEGFC，癌胚抗原（CEA）、糖类抗原125（CA125）、糖类抗原19-9（CA19-9）均明显降低，总有效率（ORR）71.67%，疾病控制率（DCR）为90.00%，无变化18.33%，进展为10.00%；2年生存率为93.33%。结论 超选择动脉KMG化疗栓塞联合RFA是治疗中央型肺癌的有效方法，近期及远期疗效好，提高患者生活质量，延长患者的生存期。Objective To investigate the curative effect of kelp micro gelation （KGM） for bronchi arterial chemoembolization （BACE） combined with radiofrequency ablation （RFA） for central lung cancer.Methods 60 patients pathologically confirmed as the central lung cancer were enrolled and performed with BACE＋KGM after the tumor-feeding artery was confirmed.RFA was performed under local anesthesia 1 month later. 1 month, 3 months and 6 months after the treatments CT scan was performed to show the changes of the tumor. Tumor markers were detected by blood test 1 month before and after the treatments. Up to the end of this study.Improvements of clinical symptoms and complications were also evaluated.Results Among the 60 patients under the treatment of BACE＋KMG＋RFA, 10 patients had a complete remission（CR）, 33 patients in partial remission （PR）, 11 patients in stable （SD） and 6 patients in progress （PD）. 1 month after the treatments, VEGFA, VEGFB, VEGFC, CEA, CA125 and CA19-9 were significantly decreased, with the overall reactive rate （ORR） of 71.67 %, disease control rate （DCR） of 90.00 %, 18.33 % of no change,10.00% progressing and the 2 year survival rate was 93.33 %.Conclusion BACE＋KMG combined RFA is an effective treatment for central lung cancer with better short-term and long-term effect, improving the life quality and survival time of patients significantly.

关 键 词：海藻酸钠微球 栓塞 射频消融 中央型肺癌 

分 类 号：R815[医药卫生—放射医学] R734.2[医药卫生—临床医学]