盐酸帕洛诺司琼注射液与注射用地塞米松磷酸钠的配伍相容性研究  

Compatibility and stability of palonosetron hydrochloride and dexamethasone sodium phosphate in infusion solutions

作　　者：杨金玉 雷凯 何光照 张程亮 刘异[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院药学部,湖北武汉430030

出　　处：《中国医院药学杂志》2017年第21期2187-2190,共4页Chinese Journal of Hospital Pharmacy

摘　　要：目的:考察盐酸帕洛诺司琼注射液与注射用地塞米松磷酸钠在输液中的配伍相容性。方法:在室温(25℃)不避光的环境条件下,对盐酸帕洛诺司琼和地塞米松磷酸钠配伍液,于0,3,6,24 h时间点观察配伍液的外观,同时测定配伍液的pH值和微粒的变化,并采用高效液相法测定配伍液中的药物浓度。结果:上述配伍输液在24 h内均无浑浊、无变色、无沉淀和气体产生,不溶性微粒符合规定标准,pH和2种药物浓度保持恒定。结论:在室温下,盐酸帕洛诺司琼与地塞米松磷酸钠在常用输液中稳定,可在临床中配伍使用。OBJECTIVE To evaluate the physical and chemical stability of palonosetron hydrochloride and dexamethasone sodium phosphate in infusion solutions. METHODS The appearance of the infusion solution was observed at 0, 3, 6, 24 h after palonosetron hydrochloride was mixed with dexamethasone sodium phosphate at room temperature （25℃）. The drug concentration of the solutions was evaluated by using high performance liquid chromatography. The pH value and particle changes were also determined. RESULTS The above mentioned infusion was not turbid within 24 hours after mixed, and showed no discoloration, precipitation or gas production. Meanwhile, insoluble particles met the specified standards, pH value and drug concentrations also remained constant. CONCLUSION Palonosetron hydrochloride and dexamethasone sodium phosphate are stable in the commonly used infusions at room temperature, and can be mixed in clinical practice.

关 键 词：盐酸帕洛诺司琼 地塞米松磷酸钠 配伍 相容性 

分 类 号：R944[医药卫生—药剂学]