去甲基构树宁B的合成  

Synthesis of Demethylbroussonin B

作　　者：樊宏宇 张羽 

机构地区：[1]大连富生天然药物开发有限公司,辽宁大连116000 [2]吉林大学药学院,吉林长春130021

出　　处：《合成化学》2017年第11期948-952,共5页Chinese Journal of Synthetic Chemistry

摘　　要：以1,3-二羟基苯和对羟基苯甲醛为起始原料,经赫氏酰化、羟基保护、克莱森-斯密特缩合及催化氢化反应首次合成天然产物去甲基构树宁B,总收率40.9%,其结构经~1H NMR,^(13)C NMR和HR-MS(ESI-TOF)确证。The synthesis of natural product demethylbroussonin B with the over yield of 40.9% was firstly achieved through Houben-Hoesch reaction, hydroxyl protection, claisen-schmidt condensation reaction and catalytic hydrogenation, using 2,4-dihydroxy acetophenone and p-hydroxyhenzaldehyde as the starting materials. The structure was confirmed by I H NMR, 13C NMR and HR-MS（ESI-TOF）.

关 键 词：构树宁 1 3-二芳基丙烷 催化氢化 药物合成 

分 类 号：O621.3[理学—有机化学]