艾纳香中艾片纯化工艺研究  

Study on the Purification Technology of L-borneolum in Blumea balsamifera

作　　者：王秋萍 何珺[2,3] 王黔阳[3] 康冀川 

机构地区：[1]贵州农业职业学院,贵州清镇551400 [2]贵州大学药学院,贵州贵阳550025 [3]贵州省生化工程中心,贵州贵阳550025

出　　处：《云南农业大学学报（自然科学版）》2017年第5期889-894,共6页Journal of Yunnan Agricultural University:Natural Science

基　　金：贵州省中药民族药制药工程研究生工作站创新基金(黔教研合JYSZ字[2014]002-04);贵州省优秀青年科技人才基金(黔科合作人才[2017]5616)

摘　　要：【目的】为得到符合《中国药典(2015版)》标准且得率与纯度均较高的艾片提供技术依据。【方法】以艾片得率和L-龙脑含量为考察指标,对比升华法、重结晶法对艾粉的纯化效果,对影响艾片纯化工艺的原料、溶剂、析晶时间、析晶温度、工艺等因素进行筛选及工艺的中试放大。【结果】2种纯化方法所得艾片均符合《中国药典(2015版)》,综合的重结晶法较好;其工艺流程:艾粉粗提物抽滤,石油醚溶解,无水硫酸镁除水,趁热过滤,滤液减压浓缩(30℃,0.01~0.08 MPa),得中间产物83.9%,然后石油醚饱和溶解,室温重结晶,抽滤,阴干,即得艾片。该工艺可使左旋龙脑含量大于95%,回收率大于80%。【结论】该方法为艾片的纯化提供一种新的工艺路线。[Purpose]The aim of this study was to provide technological references for the purification technology of L-borneolum which conformed to the standards of Chinese Pharmacopoeia（ 2015 Edition）and have a higher yield and content. [Method] The yield and content of L-borneolum were used as the indexes,to study the conditions and effects of purification of sublimation,recrystallization and steam distillation of L-borneolum. [Results]Two methods were conformed to the standards of Chinese Pharmacopoeia（ 2015 Edition L-borneolum; purification techn）,and recrystallization was better. The process parameters are to select the squeezed blumea-oil powders as raw material dissolve in petroleum ether in water bath,remove the additional water with anhydrous magnesium sulfate,the solution was filtered and concentrated（ 30 ℃,0. 01 ~ 0. 0 8 MPa）,the products were obtained and the content of L-borneol in it was 83. 9%. Then the products absolutely dissolved in the petroleum ether at room temperature,95% L-borneol was gained by recrystallizating,filtrating and drying. The recovery rate ofborneol can reach about 80%,the process is feasible. [Conclusion] This method provides a new technology route for the purification of L-borneolum.

关 键 词：艾纳香 艾片 纯化工艺 HPLC-RID 

分 类 号：R284.2[医药卫生—中药学]