酚妥拉明联合党参补肺汤治疗婴幼儿喘息性疾病的临床疗效及其对肺功能的影响  

Clinical therapeutic effects and pulmonary function effects of phentolamine combined with Dangshen Bufei Decoction in the treatment of asthmatic disease in infants

作　　者：赵莉[1] 李芳[2] 耿少怡[1] 

机构地区：[1]河北省中医院儿科,河北石家庄050011 [2]沧州中西医结合医院呼吸科,河北沧州061001

出　　处：《中成药》2017年第11期2259-2263,共5页Chinese Traditional Patent Medicine

基　　金：河北省科技厅项目(15277712D)

摘　　要：目的探讨酚妥拉明联合党参补肺汤(黄芪、党参、白术等)治疗婴幼儿喘息性疾病的临床疗效及其对肺功能的影响。方法选择2013年8月到2016年4月在我院进行诊治的婴幼儿喘息性疾病94例,随机分为观察组与对照组各47例。对照组给予酚妥拉明治疗,观察组给予酚妥拉明联合党参补肺汤治疗,两组均治疗7 d。结果治疗后观察组与对照组的总有效率分别为97.9%和85.1%,观察组的总有效率明显高于对照组(P<0.05)。观察组呼吸困难、咳嗽、发热等症状的消失时间明显快于对照组(P<0.05)。观察组面色潮红、烦躁不安、心动过速、恶心呕吐等不良反应总发生率为17.0%,对照组为19.1%,两组对比无明显差异(P>0.05)。观察组与对照组治疗后的CD4+值明显低于治疗前(P<0.05),而CD8+值明显高于治疗前(P<0.05),治疗后观察组的CD4+和CD8+值与对照组对比差异也有统计学意义(P<0.05)。观察组与对照组治疗后的FVC值分别为(83.55±15.29)%和(75.20±11.49)%,都明显高于治疗前的(68.24±15.20)%和(69.01±14.03)%(P<0.05),观察组治疗后的FVC值也明显高于对照组(P<0.05)。结论酚妥拉明联合党参补肺汤治疗婴幼儿喘息性疾病具有良好的安全性,能改善临床症状和免疫功能,从而促进肺功能和治疗效果的改善。AIM To investigate the clinical therapeutic effects and pulmonary function effects of phentolamine combined with Dangshen Bufei Decoction（Astragali Radix,Codonopsis Radix,Atractylodis macrocephalae Rhizoma,etc.） in the treatment of asthmatic disease in infants. METHODS From August 2013 to April 2016,94 cases of infants with asthmatic disease in our hospital for diagnosis and treatment were selected and randomly divided into observation group of 47 cases and control group of 47 cases. The control group was given phentolamine treatment,while the observation group was treated with phentolamine combined with Dangshen Bufei Decoction. Two groups were both treated for seven days. RESULTS The total effective rates in the observation group and the control group were 97. 9% and 85. 1%,respectively,the total effective rate in the observation group was significantly higher than that in the control group（P 〈 0. 05）. The total disappearance time of dyspnea,cough,fever and other symptoms in the observation group were significantly faster than those in the control group（P 〈 0. 05）. The incidence rate of facial flushing,irritability,bradycardia,nausea,vomiting and other adverse reactions in the observation group was 17. 0%,which was 19. 1% in the control group,there was no significant difference between the two groups（P 〉 0. 05）. CD4＋values in the observation group and the control group after the treatment were significantly lower than those before the treatment（P 〈 0. 05）,while CD8＋values were significantly higher than those before the treatment（P 〈 0. 05）. After the treatment,CD4＋and CD8＋values in the observation group showed significant statistical differences as compared with those in the control group（P 〈 0. 05）. FVC values in the observation group and the control group after the treatment were（83. 55 ± 15. 29） % and（75. 20 ± 11. 49） %,respectively,which were significantly higher than those before the treatment [（68. 24 ± 15. 20） % and（69. 01 ±14. 03） %,res

关 键 词：酚妥拉明 党参补肺汤 婴幼儿 喘息性疾病 肺功能 免疫功能 

分 类 号：R287[医药卫生—中药学]