呋塞米在APTS与石墨烯复合修饰碳糊电极上的电化学行为及电分析方法研究  

Electrocatalytic Behaviors of Furosemide at APTS and Graphene Modified Carbon Paste Electrode and Its Electrochemical Determination

作　　者：吴锐[1] 田碧桃 马少宁[1] 陈纪文[1] 高作宁[3,4] 

机构地区：[1]银川能源学院石油化工系,宁夏银川750100 [2]宁夏出入境检验检疫局,宁夏银川750100 [3]宁夏大学化学化工学院,宁夏银川750021 [4]宁夏宝塔化工中心实验室,宁夏银川750100

出　　处：《分析测试学报》2017年第11期1333-1338,共6页Journal of Instrumental Analysis

基　　金：银川能源学院科研资助项目(2015-KY-Y-01)

摘　　要：研究了呋塞米(FUR)在3-氨基丙基三氧基硅烷(APTS)和石墨烯(RGO)复合修饰碳糊电极(APTSRGO/CPE)上的电化学行为。实验结果表明,与CPE相比,APTS-RGO/CPE对呋塞米的电化学氧化显著增强,其氧化峰电流增加3.4倍。同时采用循环伏安法(CV)、计时电流法(CA)测定了FUR在APTS-RGO/CPE上的电极反应动力学参数,用微分脉冲伏安法(DPV)测得FUR氧化峰电流与浓度的线性范围为1.3~330 mg/L,检出限(LOD,S/N=3)为1.1×10-2mg/L。将该修饰电极应用于市售呋塞米片剂的检测,相对标准偏差(RSD)为0.4%~4.4%,回收率为98.5%~99.7%,检测结果符合电化学定量测定要求。In this paper,the electrochemical behavior of furosemide（FUR） at 3-anminopro-pyltriethoxsilane（APTS） and graphene（RGO） modified carbon paste electrode（APTS-RGO/CPE） was studied.The experimental results indicated that compared with CPE,APTS-RGO/CPE showed a good promotion towards FUR electrochemical oxidation,and the oxidation peak current increased significantly.Cyclic voltammetry（CV） and chronoamperometry（CA） were used to determine the reaction kinetics parameters of FUR on the APTS-RGO/CPE electrode.The relationship between FUR oxidation peak current and its concentration was evaluated by differential pulse voltammetry（DPV）.The oxidation peak current of FUR and its concentration has a good linear relationship in the concentration range of 1.3-330 mg/L with the limit of detection（S/N=3） of 1.1×10-2 mg/L.The proposed method was successfully applied in the determination of commercial tablet samples,with their relative standard deviations of 0.4%-4.4%and recoveries of 98.5%-99.7%.The results were in accord with the requirement of quantitative detection.

关 键 词：呋塞米 3-氨基丙基三氧基硅烷 石墨烯 修饰碳糊电极 电分析方法 

分 类 号：O657.1[理学—分析化学]